PRPSAP2
Summary: This gene encodes a protein that associates with the enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphoribosyl pyrophosphate synthetase associated protein 2 | MIM:603762 | Ensembl:ENSG00000141127 | HGNC:HGNC:9467 | PA33822 | 17p11.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in PRPSAP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0002189 | ribose phosphate diphosphokinase complex |
| CC | IBA | GO:0005737 | cytoplasm |
| BP | IBA | GO:0006015 | 5-phosphoribose 1-diphosphate biosynthetic process |
| BP | TAS | GO:0006139 | nucleobase-containing compound metabolic process |
| BP | IBA | GO:0006164 | purine nucleotide biosynthetic process |
| BP | IEA | GO:0009116 | nucleoside metabolic process |
| BP | IBA | GO:0009165 | nucleotide biosynthetic process |
| BP | IEA | GO:0009165 | nucleotide biosynthetic process |
| BP | IEA | GO:0043086 | negative regulation of catalytic activity |
| BP | IEA | GO:0060348 | bone development |
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | IEA | GO:0004749 | ribose phosphate diphosphokinase activity |
| MF | TAS | GO:0004857 | enzyme inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0030234 | enzyme regulator activity |
Gene expression in normal tissue: PRPSAP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRPSAP2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRPSAP2
CLASSFICATION
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