PRPSAP2

Summary: This gene encodes a protein that associates with the enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namephosphoribosyl pyrophosphate synthetase associated protein 2
OMIM IDMIM:603762
Ensembl IDEnsembl:ENSG00000141127
HGNC IDHGNC:HGNC:9467
PHARMGKB IDPA33822
Map Location17p11.2

Gene Categories:

DRUGGABLE GENOME

GO terms in PRPSAP2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0002189 ribose phosphate diphosphokinase complex
CC IBA GO:0005737 cytoplasm
BP IBA GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process
BP TAS GO:0006139 nucleobase-containing compound metabolic process
BP IBA GO:0006164 purine nucleotide biosynthetic process
BP IEA GO:0009116 nucleoside metabolic process
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Gene expression in normal tissue: PRPSAP2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

RTK signaling1

Pathways in PRPSAP2


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD748 PHA-665752 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRPSAP2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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