IQGAP1


Summary: This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in IQGAP1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0001726 ruffle
CC IDA GO:0005634 nucleus
CC IDA GO:0005737 cytoplasm
CC TAS GO:0005829 cytosol
CC IDA GO:0005874 microtubule
CC TAS GO:0005884 actin filament
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Gene expression in normal tissue: IQGAP1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

RTK signaling1

Pathways in IQGAP1


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Database
Pathway ID
Pathway Des.
wikipathways WP1993 Angiogenesis overview
wikipathways WP3888 VEGFA-VEGFR2 Signaling Pathway
wikipathways WP4180 Ebola Virus Pathway on Host
wikipathways WP4217 Ebola Virus Pathway on Host
wikipathways WP437 EGF-EGFR Signaling Pathway
wikipathways WP51 Regulation of Actin Cytoskeleton
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD748 PHA-665752 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IQGAP1

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
ISOF(IQGAP1 ENST00000559809) gene 29066719 undefined PANCAN PHA-665752 resistance in vitro
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