IQGAP1
Summary: This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:603379 Ensembl IDEnsembl:ENSG00000140575 HGNC IDHGNC:HGNC:6110 PHARMGKB IDPA29910 Map Location15q26.1 |
GO terms in IQGAP1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0001726 | ruffle |
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005737 | cytoplasm |
CC | TAS | GO:0005829 | cytosol |
CC | IDA | GO:0005874 | microtubule |
CC | TAS | GO:0005884 | actin filament |
Gene expression in normal tissue: IQGAP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IQGAP1
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP1993 | Angiogenesis overview |
wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
wikipathways | WP4180 | Ebola Virus Pathway on Host |
wikipathways | WP4217 | Ebola Virus Pathway on Host |
wikipathways | WP437 | EGF-EGFR Signaling Pathway |
wikipathways | WP51 | Regulation of Actin Cytoskeleton |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD748 | PHA-665752 | 1 |
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Gene in drug-gene network: Network Plot
