NPL


Summary: This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

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GO terms in NPL


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF ISS GO:0008747 N-acetylneuraminate lyase activity
MF TAS GO:0008747 N-acetylneuraminate lyase activity
MF IPI GO:0042802 identical protein binding
BP IEA GO:0005975 carbohydrate metabolic process
BP IEA GO:0019262 N-acetylneuraminate catabolic process
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Gene expression in normal tissue: NPL

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

RTK signaling1

Pathways in NPL


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Database
Pathway ID
Pathway Des.
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-4085001 Sialic acid metabolism
reactome R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
reactome R-HSA-446203 Asparagine N-linked glycosylation
reactome R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
reactome R-HSA-597592 Post-translational protein modification
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD748 PHA-665752 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NPL

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Cancer
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