NPL
Summary: This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:611412 Ensembl IDEnsembl:ENSG00000135838 HGNC IDHGNC:HGNC:16781 PHARMGKB IDPA25602 Map Location1q25.3 | |||||
GO terms in NPL
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008747 | N-acetylneuraminate lyase activity |
| MF | TAS | GO:0008747 | N-acetylneuraminate lyase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| BP | IEA | GO:0005975 | carbohydrate metabolic process |
| BP | IEA | GO:0019262 | N-acetylneuraminate catabolic process |
Gene expression in normal tissue: NPL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NPL
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4085001 | Sialic acid metabolism |
| reactome | R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD748 | PHA-665752 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NPL
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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