ATL1


Summary: The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:606439
PHARMGKB IDPA36061
Map Location14q22.1

GO terms in ATL1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0007029 endoplasmic reticulum organization
BP ISS GO:0007409 axonogenesis
BP IDA GO:0051260 protein homooligomerization
BP IMP GO:1990809 endoplasmic reticulum tubular network membrane organization
CC ISS GO:0000137 Golgi cis cisterna
CC IEA GO:0000139 Golgi membrane
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Gene expression in normal tissue: ATL1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

RTK signaling1

Pathways in ATL1


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD748 PHA-665752 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATL1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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