ATL1
Summary: The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606439 Ensembl IDEnsembl:ENSG00000198513 HGNC IDHGNC:HGNC:11231 PHARMGKB IDPA36061 Map Location14q22.1 | |||||
GO terms in ATL1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0007029 | endoplasmic reticulum organization |
| BP | ISS | GO:0007409 | axonogenesis |
| BP | IDA | GO:0051260 | protein homooligomerization |
| BP | IMP | GO:1990809 | endoplasmic reticulum tubular network membrane organization |
| CC | ISS | GO:0000137 | Golgi cis cisterna |
| CC | IEA | GO:0000139 | Golgi membrane |
Gene expression in normal tissue: ATL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATL1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD748 | PHA-665752 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATL1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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