RCC1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| regulator of chromosome condensation 1 | MIM:179710 | Ensembl:ENSG00000180198 | HGNC:HGNC:1913 | PA26449 | 1p35.3 |
Gene Categories:
TUMOR SUPPRESSORGO terms in RCC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0005087 | Ran guanyl-nucleotide exchange factor activity |
| MF | IMP | GO:0005087 | Ran guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005087 | Ran guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008536 | Ran GTPase binding |
| MF | IMP | GO:0031491 | nucleosome binding |
| MF | IDA | GO:0031492 | nucleosomal DNA binding |
| MF | IDA | GO:0042393 | histone binding |
| MF | IDA | GO:0043199 | sulfate binding |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| CC | IDA | GO:0000785 | chromatin |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0000794 | condensed nuclear chromosome |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0031965 | nuclear membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| BP | IMP | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IDA | GO:0007052 | mitotic spindle organization |
| BP | IMP | GO:0007059 | chromosome segregation |
| BP | IDA | GO:0007088 | regulation of mitotic nuclear division |
| BP | TAS | GO:0016032 | viral process |
| BP | IMP | GO:0051225 | spindle assembly |
| BP | IDA | GO:0051290 | protein heterotetramerization |
| BP | IEA | GO:0051301 | cell division |
Gene expression in normal tissue: RCC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RCC1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | npcpathway | mechanism of protein import into the nucleus |
| biocarta | ranmspathway | role of ran in mitotic spindle regulation |
| biocarta | ranpathway | cycling of ran in nucleocytoplasmic transport |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-165054 | Rev-mediated nuclear export of HIV RNA |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-180746 | Nuclear import of Rev protein |
| reactome | R-HSA-5663205 | Infectious disease |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RCC1
CLASSFICATION
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