SYT5
Summary: Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namesynaptotagmin 5 OMIM IDMIM:600782 Ensembl IDEnsembl:ENSG00000129990 HGNC IDHGNC:HGNC:11513 PHARMGKB IDPA36294 Map Location19q13.42|11p | |||||
GO terms in SYT5
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006906 | vesicle fusion |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | IBA | GO:0016079 | synaptic vesicle exocytosis |
| BP | IBA | GO:0017158 | regulation of calcium ion-dependent exocytosis |
| BP | IBA | GO:0048488 | synaptic vesicle endocytosis |
| BP | IBA | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter |
Gene expression in normal tissue: SYT5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SYT5
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD748 | PHA-665752 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SYT5
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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