MIR199B
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microRNA 199b | MIM:614791 | Ensembl:ENSG00000207581 | HGNC:HGNC:31573 | PA164722571 | 9q34.11 |
GO terms in MIR199B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:1903231 | mRNA binding involved in posttranscriptional gene silencing |
| BP | ISS | GO:0000320 | re-entry into mitotic cell cycle |
| BP | ISS | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
| BP | IDA | GO:0035195 | gene silencing by miRNA |
| BP | IEA | GO:0035195 | gene silencing by miRNA |
| BP | ISS | GO:0045603 | positive regulation of endothelial cell differentiation |
| BP | ISS | GO:0045765 | regulation of angiogenesis |
| BP | ISS | GO:0045766 | positive regulation of angiogenesis |
| BP | ISS | GO:0050714 | positive regulation of protein secretion |
| BP | ISS | GO:0051151 | negative regulation of smooth muscle cell differentiation |
| BP | ISS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | ISS | GO:0060044 | negative regulation of cardiac muscle cell proliferation |
| BP | ISS | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| BP | ISS | GO:0061052 | negative regulation of cell growth involved in cardiac muscle cell development |
| BP | ISS | GO:1900239 | regulation of phenotypic switching |
| BP | ISS | GO:1905180 | positive regulation of cardiac muscle tissue regeneration |
| BP | ISS | GO:1905203 | regulation of connective tissue replacement |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0035068 | micro-ribonucleoprotein complex |
Gene expression in normal tissue: MIR199B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MIR199B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2059 | Alzheimers Disease |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MIR199B
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