Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

microRNA 199bMIM:614791Ensembl:ENSG00000207581HGNC:HGNC:31573PA1647225719q34.11

GO terms in MIR199B

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:1903231mRNA binding involved in posttranscriptional gene silencing
BPISSGO:0000320re-entry into mitotic cell cycle
BPISSGO:0010667negative regulation of cardiac muscle cell apoptotic process
BPIDAGO:0035195gene silencing by miRNA
BPIEAGO:0035195gene silencing by miRNA
BPISSGO:0045603positive regulation of endothelial cell differentiation
BPISSGO:0045765regulation of angiogenesis
BPISSGO:0045766positive regulation of angiogenesis
BPISSGO:0050714positive regulation of protein secretion
BPISSGO:0051151negative regulation of smooth muscle cell differentiation
BPISSGO:0051897positive regulation of protein kinase B signaling
BPISSGO:0060044negative regulation of cardiac muscle cell proliferation
BPISSGO:0060045positive regulation of cardiac muscle cell proliferation
BPISSGO:0061052negative regulation of cell growth involved in cardiac muscle cell development
BPISSGO:1900239regulation of phenotypic switching
BPISSGO:1905180positive regulation of cardiac muscle tissue regeneration
BPISSGO:1905203regulation of connective tissue replacement
CCHDAGO:0005615extracellular space
CCIEAGO:0035068micro-ribonucleoprotein complex

Gene expression in normal tissue: MIR199B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MIR199B

DatabasePathway IDPathway Des.
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2059Alzheimers Disease
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MIR199B