ZFP36
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ZFP36 ring finger protein | MIM:190700 | Ensembl:ENSG00000128016 | HGNC:HGNC:12862 | PA37451 | 19q13.2 |
GO terms in ZFP36
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0000165 | MAPK cascade |
| BP | IDA | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| BP | IMP | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
| BP | IDA | GO:0006402 | mRNA catabolic process |
| BP | IDA | GO:0009611 | response to wounding |
| BP | ISS | GO:0009611 | response to wounding |
| BP | IMP | GO:0010837 | regulation of keratinocyte proliferation |
| BP | IDA | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay |
| BP | IDA | GO:0032680 | regulation of tumor necrosis factor production |
| BP | IMP | GO:0032897 | negative regulation of viral transcription |
| BP | ISS | GO:0035278 | miRNA mediated inhibition of translation |
| BP | ISS | GO:0038066 | p38MAPK cascade |
| BP | IDA | GO:0042594 | response to starvation |
| BP | IDA | GO:0043488 | regulation of mRNA stability |
| BP | IMP | GO:0043488 | regulation of mRNA stability |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | IDA | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| BP | ISS | GO:0045085 | negative regulation of interleukin-2 biosynthetic process |
| BP | ISS | GO:0045600 | positive regulation of fat cell differentiation |
| BP | IMP | GO:0045616 | regulation of keratinocyte differentiation |
| BP | IDA | GO:0045647 | negative regulation of erythrocyte differentiation |
| BP | IMP | GO:0051028 | mRNA transport |
| BP | IDA | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| BP | IBA | GO:0061158 | 3'-UTR-mediated mRNA destabilization |
| BP | IDA | GO:0061158 | 3'-UTR-mediated mRNA destabilization |
| BP | IMP | GO:0061158 | 3'-UTR-mediated mRNA destabilization |
| BP | IDA | GO:0070935 | 3'-UTR-mediated mRNA stabilization |
| BP | IDA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IMP | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IDA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IDA | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IDA | GO:0071385 | cellular response to glucocorticoid stimulus |
| BP | IDA | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus |
| BP | IDA | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| BP | ISS | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| BP | IDA | GO:1901835 | positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA |
| BP | IMP | GO:1902172 | regulation of keratinocyte apoptotic process |
| BP | ISS | GO:1904246 | negative regulation of polynucleotide adenylyltransferase activity |
| BP | IMP | GO:1904582 | positive regulation of intracellular mRNA localization |
| BP | IMP | GO:2000637 | positive regulation of gene silencing by miRNA |
| CC | IDA | GO:0000178 | exosome (RNase complex) |
| CC | IDA | GO:0000932 | P-body |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0010494 | cytoplasmic stress granule |
| CC | ISS | GO:0030014 | CCR4-NOT complex |
| CC | IDA | GO:0070578 | RISC-loading complex |
| CC | IDA | GO:0098745 | Dcp1-Dcp2 complex |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
| MF | IEA | GO:0003677 | DNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0003727 | single-stranded RNA binding |
| MF | IDA | GO:0003729 | mRNA binding |
| MF | IBA | GO:0003730 | mRNA 3'-UTR binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0017091 | AU-rich element binding |
| MF | IMP | GO:0017091 | AU-rich element binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019957 | C-C chemokine binding |
| MF | IDA | GO:0031072 | heat shock protein binding |
| MF | IDA | GO:0035925 | mRNA 3'-UTR AU-rich region binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | ISS | GO:0070063 | RNA polymerase binding |
| MF | IDA | GO:0071889 | 14-3-3 protein binding |
Gene expression in normal tissue: ZFP36
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZFP36
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP3527 | Preimplantation Embryo |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| reactome | R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZFP36
CLASSFICATION
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