ADH5
Summary: This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| alcohol dehydrogenase 5 (class III), chi polypeptide | MIM:103710 | Ensembl:ENSG00000197894 | HGNC:HGNC:253 | PA24574 | 4q23 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ADH5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001523 | retinoid metabolic process |
| BP | IEA | GO:0003016 | respiratory system process |
| BP | TAS | GO:0006069 | ethanol oxidation |
| BP | IEA | GO:0018119 | peptidyl-cysteine S-nitrosylation |
| BP | IEA | GO:0022900 | electron transport chain |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0045777 | positive regulation of blood pressure |
| BP | IEA | GO:0046294 | formaldehyde catabolic process |
| BP | IEA | GO:0051409 | response to nitrosative stress |
| BP | IDA | GO:0051775 | response to redox state |
| MF | IEA | GO:0004022 | alcohol dehydrogenase (NAD) activity |
| MF | IDA | GO:0005504 | fatty acid binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | TAS | GO:0009055 | electron transfer activity |
| MF | IDA | GO:0018467 | formaldehyde dehydrogenase activity |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | TAS | GO:0051903 | S-(hydroxymethyl)glutathione dehydrogenase activity |
Gene expression in normal tissue: ADH5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADH5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211945 | Phase I - Functionalization of compounds |
| reactome | R-HSA-71384 | Ethanol oxidation |
| wikipathways | WP1589 | Folate-Alcohol and Cancer Pathway Hypotheses |
| wikipathways | WP3925 | Amino Acid metabolism |
| pharmgkb | PA2035 | Cyclophosphamide Pathway, Pharmacodynamics |
| pharmgkb | PA2038 | Ifosfamide Pathway, Pharmacodynamics |
| humancyc | PWY-1801 | formaldehyde oxidation |
| kegg | hsa00010 | Glycolysis / Gluconeogenesis - Homo sapiens (human) |
| kegg | hsa00071 | Fatty acid degradation - Homo sapiens (human) |
| kegg | hsa00350 | Tyrosine metabolism - Homo sapiens (human) |
| kegg | hsa00830 | Retinol metabolism - Homo sapiens (human) |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADH5
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