UBA2
Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:613295 Ensembl IDEnsembl:ENSG00000126261 HGNC IDHGNC:HGNC:30661 PHARMGKB IDPA162407583 Map Location19q13.11 | |||||
GO terms in UBA2
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0016925 | protein sumoylation |
| BP | IDA | GO:0016925 | protein sumoylation |
| BP | IEA | GO:0016925 | protein sumoylation |
| BP | IMP | GO:0016925 | protein sumoylation |
| BP | TAS | GO:0016925 | protein sumoylation |
| BP | IEA | GO:0043085 | positive regulation of catalytic activity |
Gene expression in normal tissue: UBA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UBA2
Loading, please wait...
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3065676 | SUMO is conjugated to E1 (UBA2:SAE1) |
| reactome | R-HSA-3065676 | SUMO is conjugated to E1 (UBA2:SAE1) |
| reactome | R-HSA-3065678 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD748 | PHA-665752 | 1 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UBA2
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.