TDH
Summary: This gene appears to be an evolving pseudogene of L-threonine 3-dehydrogenase (TDH). In both prokaryotes and eukaryotes, TDH catalyzes the first of two steps in one of two L-threonine degradation pathways. However, in human, the single gene with sequence similarity to TDH is not capable of encoding a functional TDH protein; the predicted protein lacks most of the C-terminus and parts of the NAD+ binding motif when compared to other species' TDH proteins. This suggests that the human gene is therefore a pseudogene. Transcripts of this gene are found in all tissues and alternatively spliced transcripts have been described. It is not known if these transcripts are translated, or if the possible protein product provides any functional role. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| L-threonine dehydrogenase (pseudogene) | MIM:615174 | Ensembl:ENSG00000154316 | HGNC:HGNC:15547 | PA37977 | 8p23.1 |
GO terms in TDH
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003824 | catalytic activity |
| MF | IEA | GO:0050662 | coenzyme binding |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
Gene expression in normal tissue: TDH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TDH
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TDH
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