ADCY2
Summary: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:103071 Ensembl IDEnsembl:ENSG00000078295 HGNC IDHGNC:HGNC:233 PHARMGKB IDPA24561 Map Location5p15.31 | |||||
GO terms in ADCY2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0000287 | magnesium ion binding |
| MF | ISS | GO:0004016 | adenylate cyclase activity |
| MF | NAS | GO:0004016 | adenylate cyclase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | ISS | GO:0008179 | adenylate cyclase binding |
| MF | ISS | GO:0030145 | manganese ion binding |
Gene expression in normal tissue: ADCY2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADCY2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111931 | PKA-mediated phosphorylation of CREB |
| reactome | R-HSA-111933 | Calmodulin induced events |
| reactome | R-HSA-111996 | Ca-dependent events |
| reactome | R-HSA-111997 | CaM pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADCY2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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