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MRAP2

Summary: This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namemelanocortin 2 receptor accessory protein 2 OMIM IDMIM:615410 Ensembl IDEnsembl:ENSG00000135324 HGNC IDHGNC:HGNC:21232 PHARMGKB IDPA162396161 Map Location6q14.2

GO terms in MRAP2

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0031780	corticotropin hormone receptor binding
MF	IPI	GO:0031781	type 3 melanocortin receptor binding
MF	IPI	GO:0031782	type 4 melanocortin receptor binding
MF	IPI	GO:0031783	type 5 melanocortin receptor binding
MF	IPI	GO:0042802	identical protein binding

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Gene expression in normal tissue: MRAP2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MRAP2

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Database	Pathway ID	Pathway Des.
No matching records found

Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD748	PHA-665752	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MRAP2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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