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NECAB2

Summary: The protein encoded by this gene is a neuronal calcium-binding protein that binds to and modulates the function of at least two receptors, adenosine A(2A) receptor and metabotropic glutamate receptor type 5. [provided by RefSeq, Jul 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
N-terminal EF-hand calcium binding protein 2		Ensembl:ENSG00000103154	HGNC:HGNC:23746	PA162397412	16q23.3

GO terms in NECAB2

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IBA	GO:0005737	cytoplasm
CC	IEA	GO:0005737	cytoplasm
CC	IDA	GO:0005886	plasma membrane
CC	IEA	GO:0030424	axon
CC	IEA	GO:0030425	dendrite
BP	IBA	GO:0042984	regulation of amyloid precursor protein biosynthetic process
BP	IDA	GO:0060168	positive regulation of adenosine receptor signaling pathway
BP	IDA	GO:0070374	positive regulation of ERK1 and ERK2 cascade
BP	IDA	GO:1900451	positive regulation of glutamate receptor signaling pathway
BP	IDA	GO:1904021	negative regulation of G-protein coupled receptor internalization
BP	IDA	GO:1905477	positive regulation of protein localization to membrane
MF	IEA	GO:0005509	calcium ion binding
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0031687	A2A adenosine receptor binding
MF	IDA	GO:0031802	type 5 metabotropic glutamate receptor binding

Gene expression in normal tissue: NECAB2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NECAB2

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD748	PHA-665752	1
iGMDRD353	PD0325901	1
iGMDRD309	17AAG	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NECAB2

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DATATYPES

CLASSFICATION

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