AHCY
Summary: S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:180960 Ensembl IDEnsembl:ENSG00000101444 HGNC IDHGNC:HGNC:343 PHARMGKB IDPA24636 Map Location20q11.22 | |||||
GO terms in AHCY
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000096 | sulfur amino acid metabolic process |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0002439 | chronic inflammatory response to antigenic stimulus |
| BP | IEA | GO:0006730 | one-carbon metabolic process |
| BP | IEA | GO:0007584 | response to nutrient |
| BP | IEA | GO:0019510 | S-adenosylhomocysteine catabolic process |
Gene expression in normal tissue: AHCY
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AHCY
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00029 | Selenoamino Acid Metabolism |
| smpdb | SMP00033 | Methionine Metabolism |
| smpdb | SMP00123 | Betaine Metabolism |
| smpdb | SMP00177 | Cystathionine Beta-Synthase Deficiency |
| smpdb | SMP00214 | S-Adenosylhomocysteine (SAH) Hydrolase Deficiency |
| smpdb | SMP00221 | Methionine Adenosyltransferase Deficiency |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD748 | PHA-665752 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AHCY
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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