ADNP
Summary: Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| activity dependent neuroprotector homeobox | MIM:611386 | Ensembl:ENSG00000101126 | HGNC:HGNC:15766 | PA24582 | 20q13.13 |
Gene Categories:
KINASEGO terms in ADNP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IEA | GO:0005507 | copper ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0042277 | peptide binding |
| MF | IEA | GO:0048487 | beta-tubulin binding |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0007614 | short-term memory |
| BP | IEA | GO:0009743 | response to carbohydrate |
| BP | IEA | GO:0010035 | response to inorganic substance |
| BP | IEA | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0010835 | regulation of protein ADP-ribosylation |
| BP | IEA | GO:0031668 | cellular response to extracellular stimulus |
| BP | IEA | GO:0032091 | negative regulation of protein binding |
| BP | IEA | GO:0032147 | activation of protein kinase activity |
| BP | IEA | GO:0033484 | nitric oxide homeostasis |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0044849 | estrous cycle |
| BP | IEA | GO:0045773 | positive regulation of axon extension |
| BP | IEA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0050805 | negative regulation of synaptic transmission |
| BP | IEA | GO:0051965 | positive regulation of synapse assembly |
| CC | IEA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0030424 | axon |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0043025 | neuronal cell body |
Gene expression in normal tissue: ADNP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADNP
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADNP
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