PRDX4
Summary: The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameperoxiredoxin 4 OMIM IDMIM:300927 Ensembl IDEnsembl:ENSG00000123131 HGNC IDHGNC:HGNC:17169 PHARMGKB IDPA33725 Map LocationXp22.11 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in PRDX4
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008379 | thioredoxin peroxidase activity |
| MF | TAS | GO:0008379 | thioredoxin peroxidase activity |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005634 | nucleus |
Gene expression in normal tissue: PRDX4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRDX4
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP15 | Selenium Micronutrient Network |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD748 | PHA-665752 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRDX4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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