CPT1B
Summary: The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| carnitine palmitoyltransferase 1B | MIM:601987 | Ensembl:ENSG00000205560 | HGNC:HGNC:2329 | PA26848 | 22q13.33 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CPT1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004095 | carnitine O-palmitoyltransferase activity |
| MF | TAS | GO:0004095 | carnitine O-palmitoyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008374 | O-acyltransferase activity |
| BP | IBA | GO:0006631 | fatty acid metabolic process |
| BP | IEA | GO:0006635 | fatty acid beta-oxidation |
| BP | TAS | GO:0006853 | carnitine shuttle |
| BP | IBA | GO:0009437 | carnitine metabolic process |
| BP | IBA | GO:0015909 | long-chain fatty acid transport |
| CC | HDA | GO:0005739 | mitochondrion |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: CPT1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CPT1B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP143 | Fatty Acid Beta Oxidation |
| wikipathways | WP3942 | PPAR signaling pathway |
| pid | hnf3bpathway | FOXA2 and FOXA3 transcription factor networks |
| kegg | hsa00071 | Fatty acid degradation - Homo sapiens (human) |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| humancyc | PWY-6111 | mitochondrial L-carnitine shuttle |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-200425 | Import of palmitoyl-CoA into the mitochondrial matrix |
| reactome | R-HSA-5362517 | Signaling by Retinoic Acid |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CPT1B
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