SLC25A6
Summary: This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:403000 Ensembl IDEnsembl:ENSG00000169100 HGNC IDHGNC:HGNC:10992 PHARMGKB IDPA35868 Map LocationXp22.33 and Yp11.2 | |||||
GO terms in SLC25A6
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005634 | nucleus |
| CC | HDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
| CC | TAS | GO:0005744 | mitochondrial inner membrane presequence translocase complex |
| BP | TAS | GO:0006626 | protein targeting to mitochondrion |
Gene expression in normal tissue: SLC25A6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC25A6
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1268020 | Mitochondrial protein import |
| reactome | R-HSA-1268020 | Mitochondrial protein import |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-163685 | Integration of energy metabolism |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD748 | PHA-665752 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC25A6
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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