SLC25A6
Summary: This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 25 member 6 | MIM:403000 | Ensembl:ENSG00000169100 | HGNC:HGNC:10992 | PA35868 | Xp22.33 and Yp11.2 |
GO terms in SLC25A6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005634 | nucleus |
| CC | HDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
| CC | TAS | GO:0005744 | mitochondrial inner membrane presequence translocase complex |
| BP | TAS | GO:0006626 | protein targeting to mitochondrion |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0015853 | adenine transport |
| BP | IEA | GO:0015866 | ADP transport |
| BP | IEA | GO:0015867 | ATP transport |
| BP | TAS | GO:0046732 | active induction of host immune response by virus |
| BP | IBA | GO:0046902 | regulation of mitochondrial membrane permeability |
| BP | TAS | GO:0050796 | regulation of insulin secretion |
| BP | IEA | GO:0055085 | transmembrane transport |
| MF | IBA | GO:0005471 | ATP:ADP antiporter activity |
| MF | NAS | GO:0005471 | ATP:ADP antiporter activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015207 | adenine transmembrane transporter activity |
Gene expression in normal tissue: SLC25A6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC25A6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1268020 | Mitochondrial protein import |
| reactome | R-HSA-1268020 | Mitochondrial protein import |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168253 | Host Interactions with Influenza Factors |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168277 | Influenza Virus Induced Apoptosis |
| reactome | R-HSA-176033 | Interactions of Vpr with host cellular proteins |
| reactome | R-HSA-180897 | Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-5663205 | Infectious disease |
| wikipathways | WP111 | Electron Transport Chain |
| netpath | Pathway_EGFR1 | EGFR1 |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC25A6
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