Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010].

cyclin HMIM:601953Ensembl:ENSG00000134480HGNC:HGNC:1594PA261595q14.3

GO terms in CCNH

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIDAGO:0008094DNA-dependent ATPase activity
MFIDAGO:0008353RNA polymerase II carboxy-terminal domain kinase activity
MFIBAGO:0016538cyclin-dependent protein serine/threonine kinase regulator activity
CCIBAGO:0000307cyclin-dependent protein kinase holoenzyme complex
CCIDAGO:0005675holo TFIIH complex
CCIDAGO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex
CCIMPGO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex
CCIEAGO:0070985TFIIK complex
BPTASGO:0006283transcription-coupled nucleotide-excision repair
BPTASGO:0006294nucleotide-excision repair, preincision complex assembly
BPTASGO:0006361transcription initiation from RNA polymerase I promoter
BPTASGO:0006363termination of RNA polymerase I transcription
BPIDAGO:0006366transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0006368transcription elongation from RNA polymerase II promoter
BPTASGO:00063707-methylguanosine mRNA capping
BPIEAGO:0006468protein phosphorylation
BPIEAGO:0007049cell cycle
BPIBAGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0050821protein stabilization
BPIBAGO:1901409positive regulation of phosphorylation of RNA polymerase II C-terminal domain

Gene expression in normal tissue: CCNH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCNH

DatabasePathway IDPathway Des.
reactomeR-HSA-112382Formation of RNA Pol II elongation complex
reactomeR-HSA-113418Formation of the Early Elongation Complex
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162599Late Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-167152Formation of HIV elongation complex in the absence of HIV Tat
reactomeR-HSA-167158Formation of the HIV-1 Early Elongation Complex
reactomeR-HSA-167160RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
reactomeR-HSA-167161HIV Transcription Initiation
reactomeR-HSA-167162RNA Polymerase II HIV Promoter Escape
reactomeR-HSA-167169HIV Transcription Elongation
reactomeR-HSA-167172Transcription of the HIV genome
reactomeR-HSA-167200Formation of HIV-1 elongation complex containing HIV-1 Tat
reactomeR-HSA-167246Tat-mediated elongation of the HIV-1 transcript
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-427413NoRC negatively regulates rRNA expression
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-5250941Negative epigenetic regulation of rRNA expression
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5696395Formation of Incision Complex in GG-NER
reactomeR-HSA-5696398Nucleotide Excision Repair
reactomeR-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)
reactomeR-HSA-674695RNA Polymerase II Pre-transcription Events
reactomeR-HSA-6781823Formation of TC-NER Pre-Incision Complex
reactomeR-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)
reactomeR-HSA-6782135Dual incision in TC-NER
reactomeR-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NER
reactomeR-HSA-6796648TP53 Regulates Transcription of DNA Repair Genes
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69242S Phase
reactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transition
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-72086mRNA Capping
reactomeR-HSA-73762RNA Polymerase I Transcription Initiation
reactomeR-HSA-73772RNA Polymerase I Promoter Escape
reactomeR-HSA-73776RNA Polymerase II Promoter Escape
reactomeR-HSA-73777RNA Polymerase I Chain Elongation
reactomeR-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
reactomeR-HSA-73854RNA Polymerase I Promoter Clearance
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73863RNA Polymerase I Transcription Termination
reactomeR-HSA-73864RNA Polymerase I Transcription
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75953RNA Polymerase II Transcription Initiation
reactomeR-HSA-75955RNA Polymerase II Transcription Elongation
reactomeR-HSA-76042RNA Polymerase II Transcription Initiation And Promoter Clearance
reactomeR-HSA-77075RNA Pol II CTD phosphorylation and interaction with CE
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCs
reactomeR-HSA-8953854Metabolism of RNA
biocartacellcyclepathwaycyclins and cell cycle regulation
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartaptc1pathwaysonic hedgehog receptor ptc1 regulates cell cycle
pidretinoic_acid_pathwayRetinoic acid receptors-mediated signaling
kegghsa03022Basal transcription factors - Homo sapiens (human)
kegghsa03420Nucleotide excision repair - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
wikipathwaysWP179Cell Cycle
wikipathwaysWP405Eukaryotic Transcription Initiation
wikipathwaysWP45G1 to S cell cycle control

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCNH