PDE9A

Summary: The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namephosphodiesterase 9A
OMIM IDMIM:602973
Ensembl IDEnsembl:ENSG00000160191
HGNC IDHGNC:HGNC:8795
PHARMGKB IDPA33143
Map Location21q22.3

Gene Categories:

DRUGGABLE GENOME

GO terms in PDE9A


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0046872 metal ion binding
MF IDA GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
MF TAS GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
BP TAS GO:0007165 signal transduction
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Gene expression in normal tissue: PDE9A

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

RTK signaling1

Pathways in PDE9A


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-392154 Nitric oxide stimulates guanylate cyclase
reactome R-HSA-418346 Platelet homeostasis
reactome R-HSA-418457 cGMP effects
pid ar_tf_pathway Regulation of Androgen receptor activity
kegg hsa00230 Purine metabolism - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD748 PHA-665752 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDE9A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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