PDE9A
Summary: The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphodiesterase 9A | MIM:602973 | Ensembl:ENSG00000160191 | HGNC:HGNC:8795 | PA33143 | 21q22.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in PDE9A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity |
| MF | TAS | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity |
| BP | TAS | GO:0007165 | signal transduction |
| BP | ISS | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| BP | IEA | GO:0019934 | cGMP-mediated signaling |
| BP | IDA | GO:0046068 | cGMP metabolic process |
| BP | IDA | GO:0046069 | cGMP catabolic process |
| BP | IEA | GO:0046069 | cGMP catabolic process |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | HDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0032587 | ruffle membrane |
| CC | IDA | GO:0042383 | sarcolemma |
| CC | IEA | GO:0043204 | perikaryon |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: PDE9A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDE9A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-392154 | Nitric oxide stimulates guanylate cyclase |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418457 | cGMP effects |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| wikipathways | WP4222 | Phosphodiesterases in neuronal function |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDE9A
CLASSFICATION
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