INPP5F
Summary: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609389 Ensembl IDEnsembl:ENSG00000198825 HGNC IDHGNC:HGNC:17054 PHARMGKB IDPA134927878 Map Location10q26.11 | |||||
GO terms in INPP5F
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008934 | inositol monophosphate 1-phosphatase activity |
| MF | IDA | GO:0034595 | phosphatidylinositol phosphate 5-phosphatase activity |
| MF | IDA | GO:0034595 | phosphatidylinositol phosphate 5-phosphatase activity |
| MF | IDA | GO:0034596 | phosphatidylinositol phosphate 4-phosphatase activity |
| MF | TAS | GO:0034596 | phosphatidylinositol phosphate 4-phosphatase activity |
Gene expression in normal tissue: INPP5F
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INPP5F
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| humancyc | PWY-6358 | superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism |
| humancyc | PWY-6363 | D-myo-inositol (1,4,5)-trisphosphate degradation |
| humancyc | PWY-6368 | 3-phosphoinositide degradation |
| reactome | R-HSA-1430728 | Metabolism |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD748 | PHA-665752 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in INPP5F
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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