INPP5F
Summary: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| inositol polyphosphate-5-phosphatase F | MIM:609389 | Ensembl:ENSG00000198825 | HGNC:HGNC:17054 | PA134927878 | 10q26.11 |
GO terms in INPP5F
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008934 | inositol monophosphate 1-phosphatase activity |
| MF | IDA | GO:0034595 | phosphatidylinositol phosphate 5-phosphatase activity |
| MF | IDA | GO:0034595 | phosphatidylinositol phosphate 5-phosphatase activity |
| MF | IDA | GO:0034596 | phosphatidylinositol phosphate 4-phosphatase activity |
| MF | TAS | GO:0034596 | phosphatidylinositol phosphate 4-phosphatase activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity |
| MF | IEA | GO:0052832 | inositol monophosphate 3-phosphatase activity |
| MF | IEA | GO:0052833 | inositol monophosphate 4-phosphatase activity |
| CC | IBA | GO:0005769 | early endosome |
| CC | IDA | GO:0005769 | early endosome |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005905 | clathrin-coated pit |
| CC | IEA | GO:0030424 | axon |
| CC | IEA | GO:0030425 | dendrite |
| CC | TAS | GO:0031901 | early endosome membrane |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IBA | GO:0045334 | clathrin-coated endocytic vesicle |
| CC | IDA | GO:0045334 | clathrin-coated endocytic vesicle |
| CC | IDA | GO:0055037 | recycling endosome |
| CC | ISS | GO:0055037 | recycling endosome |
| BP | IDA | GO:0001921 | positive regulation of receptor recycling |
| BP | TAS | GO:0006661 | phosphatidylinositol biosynthetic process |
| BP | IEA | GO:0008344 | adult locomotory behavior |
| BP | ISS | GO:0014898 | cardiac muscle hypertrophy in response to stress |
| BP | ISS | GO:0031161 | phosphatidylinositol catabolic process |
| BP | IEA | GO:0033137 | negative regulation of peptidyl-serine phosphorylation |
| BP | IDA | GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein |
| BP | IBA | GO:0046856 | phosphatidylinositol dephosphorylation |
| BP | IDA | GO:0046856 | phosphatidylinositol dephosphorylation |
| BP | ISS | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | ISS | GO:0048681 | negative regulation of axon regeneration |
| BP | IEA | GO:0051896 | regulation of protein kinase B signaling |
| BP | ISS | GO:0072583 | clathrin-dependent endocytosis |
| BP | IMP | GO:2000145 | regulation of cell motility |
| BP | IBA | GO:2001135 | regulation of endocytic recycling |
| BP | IMP | GO:2001135 | regulation of endocytic recycling |
| BP | ISS | GO:2001135 | regulation of endocytic recycling |
Gene expression in normal tissue: INPP5F
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INPP5F
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| humancyc | PWY-6358 | superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism |
| humancyc | PWY-6363 | D-myo-inositol (1,4,5)-trisphosphate degradation |
| humancyc | PWY-6368 | 3-phosphoinositide degradation |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in INPP5F
CLASSFICATION
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