MRPL18
Summary: This nuclear gene encodes a protein component of the larger 39S subunit of mitochondrial ribosome. This protein may also aid in the import of nuclear-encoded 5S rRNA into mitochondria. Alternative splicing results in multiple transcript variants, most of which are not predicted to encode a protein. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Jan 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:611831 Ensembl IDEnsembl:ENSG00000112110 HGNC IDHGNC:HGNC:14477 PHARMGKB IDPA30947 Map Location6q25.3 |
GO terms in MRPL18
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | NAS | GO:0003735 | structural constituent of ribosome |
MF | IBA | GO:0008097 | 5S rRNA binding |
MF | IDA | GO:0008097 | 5S rRNA binding |
BP | NAS | GO:0006412 | translation |
BP | IDA | GO:0035928 | rRNA import into mitochondrion |
BP | TAS | GO:0070125 | mitochondrial translational elongation |
Gene expression in normal tissue: MRPL18
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MRPL18
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-5368286 | Mitochondrial translation initiation |
reactome | R-HSA-5368287 | Mitochondrial translation |
reactome | R-HSA-5368287 | Mitochondrial translation |
reactome | R-HSA-5389840 | Mitochondrial translation elongation |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD748 | PHA-665752 | 1 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in MRPL18
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |