MRPL18
Summary: This nuclear gene encodes a protein component of the larger 39S subunit of mitochondrial ribosome. This protein may also aid in the import of nuclear-encoded 5S rRNA into mitochondria. Alternative splicing results in multiple transcript variants, most of which are not predicted to encode a protein. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitochondrial ribosomal protein L18 | MIM:611831 | Ensembl:ENSG00000112110 | HGNC:HGNC:14477 | PA30947 | 6q25.3 |
GO terms in MRPL18
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0003735 | structural constituent of ribosome |
| MF | IBA | GO:0008097 | 5S rRNA binding |
| MF | IDA | GO:0008097 | 5S rRNA binding |
| BP | NAS | GO:0006412 | translation |
| BP | IDA | GO:0035928 | rRNA import into mitochondrion |
| BP | TAS | GO:0070125 | mitochondrial translational elongation |
| BP | TAS | GO:0070126 | mitochondrial translational termination |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
| CC | NAS | GO:0005761 | mitochondrial ribosome |
| CC | IDA | GO:0005762 | mitochondrial large ribosomal subunit |
Gene expression in normal tissue: MRPL18
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MRPL18
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5368286 | Mitochondrial translation initiation |
| reactome | R-HSA-5368287 | Mitochondrial translation |
| reactome | R-HSA-5368287 | Mitochondrial translation |
| reactome | R-HSA-5389840 | Mitochondrial translation elongation |
| reactome | R-HSA-5389840 | Mitochondrial translation elongation |
| reactome | R-HSA-5419276 | Mitochondrial translation termination |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-72766 | Translation |
| kegg | hsa03010 | Ribosome - Homo sapiens (human) |
| wikipathways | WP3395 | Cellular response to heat stress |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MRPL18
CLASSFICATION
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