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AMT

Summary: This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameaminomethyltransferase OMIM IDMIM:238310 Ensembl IDEnsembl:ENSG00000145020 HGNC IDHGNC:HGNC:473 PHARMGKB IDPA24780 Map Location3p21.31

GO terms in AMT

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004047	aminomethyltransferase activity
MF	IMP	GO:0004047	aminomethyltransferase activity
MF	TAS	GO:0004047	aminomethyltransferase activity
MF	IEA	GO:0008483	transaminase activity
BP	TAS	GO:0006546	glycine catabolic process
BP	IBA	GO:0019464	glycine decarboxylation via glycine cleavage system

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Gene expression in normal tissue: AMT

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AMT

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-389661	Glyoxylate metabolism and glycine degradation
reactome	R-HSA-6783984	Glycine degradation
reactome	R-HSA-71291	Metabolism of amino acids and derivatives
smpdb	SMP00004	Glycine and Serine Metabolism
smpdb	SMP00009	Ammonia Recycling

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD748	PHA-665752	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AMT

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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