HPCA
Summary: The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| hippocalcin | MIM:142622 | Ensembl:ENSG00000121905 | HGNC:HGNC:5144 | PA29417 | 1p35.1 |
GO terms in HPCA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007420 | brain development |
| BP | IEA | GO:0019722 | calcium-mediated signaling |
| BP | IEA | GO:0031283 | negative regulation of guanylate cyclase activity |
| BP | IEA | GO:0031584 | activation of phospholipase D activity |
| BP | IEA | GO:0045762 | positive regulation of adenylate cyclase activity |
| BP | IEA | GO:0048839 | inner ear development |
| BP | IEA | GO:0060041 | retina development in camera-type eye |
| BP | IEA | GO:0071257 | cellular response to electrical stimulus |
| BP | IMP | GO:0071277 | cellular response to calcium ion |
| BP | IEA | GO:0090314 | positive regulation of protein targeting to membrane |
| BP | IMP | GO:1901385 | regulation of voltage-gated calcium channel activity |
| BP | IEA | GO:1901986 | response to ketamine |
| BP | IEA | GO:1902065 | response to L-glutamate |
| BP | IEA | GO:1904009 | cellular response to monosodium glutamate |
| BP | IEA | GO:1904010 | response to Aroclor 1254 |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005829 | cytosol |
| CC | ISS | GO:0019898 | extrinsic component of membrane |
| CC | IEA | GO:0030424 | axon |
| CC | IEA | GO:0032590 | dendrite membrane |
| CC | IEA | GO:0032809 | neuronal cell body membrane |
| CC | IEA | GO:0032839 | dendrite cytoplasm |
| CC | IEA | GO:0043204 | perikaryon |
| CC | IEA | GO:0044327 | dendritic spine head |
| MF | IDA | GO:0003779 | actin binding |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | NAS | GO:0005509 | calcium ion binding |
| MF | IEA | GO:0019900 | kinase binding |
| MF | IDA | GO:0042802 | identical protein binding |
Gene expression in normal tissue: HPCA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HPCA
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HPCA
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