Summary: Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009].

mucolipin 2MIM:607399Ensembl:ENSG00000153898HGNC:HGNC:13357PA1349136911p22.3

GO terms in MCOLN2

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0002250adaptive immune response
BPIEAGO:0035926chemokine (C-C motif) ligand 2 secretion
BPIEAGO:0045087innate immune response
BPIEAGO:0051259protein complex oligomerization
BPTASGO:0070588calcium ion transmembrane transport
BPIEAGO:0071639positive regulation of monocyte chemotactic protein-1 production
BPIEAGO:0071642positive regulation of macrophage inflammatory protein 1 alpha production
BPIEAGO:0071651positive regulation of chemokine (C-C motif) ligand 5 production
BPIEAGO:1905517macrophage migration
BPIEAGO:1990266neutrophil migration
BPIEAGO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 production
CCIBAGO:0005765lysosomal membrane
CCIBAGO:0005765lysosomal membrane
CCIEAGO:0005765lysosomal membrane
CCIBAGO:0005886plasma membrane
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCIEAGO:0031902late endosome membrane
CCIEAGO:0055038recycling endosome membrane
MFTASGO:0005262calcium channel activity
MFIBAGO:0072345NAADP-sensitive calcium-release channel activity

Gene expression in normal tissue: MCOLN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MCOLN2

DatabasePathway IDPathway Des.
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-3295583TRP channels
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MCOLN2