ANGPT2
Summary: The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| angiopoietin 2 | MIM:601922 | Ensembl:ENSG00000091879 | HGNC:HGNC:485 | PA24792 | 8p23.1 |
GO terms in ANGPT2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0042995 | cell projection |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007281 | germ cell development |
| BP | IEA | GO:0009314 | response to radiation |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IEA | GO:0009749 | response to glucose |
| BP | IEA | GO:0010812 | negative regulation of cell-substrate adhesion |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | IEA | GO:0014823 | response to activity |
| BP | IEA | GO:0016525 | negative regulation of angiogenesis |
| BP | IEA | GO:0031100 | animal organ regeneration |
| BP | IDA | GO:0043537 | negative regulation of blood vessel endothelial cell migration |
| BP | IEA | GO:0045766 | positive regulation of angiogenesis |
| BP | IDA | GO:0048014 | Tie signaling pathway |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IDA | GO:0050928 | negative regulation of positive chemotaxis |
| BP | IEA | GO:0060135 | maternal process involved in female pregnancy |
| BP | IEA | GO:0071363 | cellular response to growth factor stimulus |
| BP | ISS | GO:0072012 | glomerulus vasculature development |
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0030971 | receptor tyrosine kinase binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ANGPT2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ANGPT2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3614 | Photodynamic therapy-induced HIF-1 survival signaling |
| wikipathways | WP3668 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210993 | Tie2 Signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ANGPT2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.