ATF3
Summary: This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603148 Ensembl IDEnsembl:ENSG00000162772 HGNC IDHGNC:HGNC:785 PHARMGKB IDPA25085 Map Location1q32.3 | |||||
GO terms in ATF3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006094 | gluconeogenesis |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0034198 | cellular response to amino acid starvation |
Gene expression in normal tissue: ATF3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATF3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2753 | ATF4 activates genes |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP3613 | Photodynamic therapy-induced unfolded protein response |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP516 | Hypertrophy Model |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD748 | PHA-665752 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATF3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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