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TOLLIP

Summary: This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
toll interacting protein	MIM:606277	Ensembl:ENSG00000078902	HGNC:HGNC:16476	PA134876213	11p15.5

GO terms in TOLLIP

Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005576	extracellular region
CC	IC	GO:0005737	cytoplasm
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0016604	nuclear body
CC	TAS	GO:0035578	azurophil granule lumen
CC	TAS	GO:0035580	specific granule lumen
CC	NAS	GO:0045092	interleukin-18 receptor complex
CC	NAS	GO:0045323	interleukin-1 receptor complex
CC	IEA	GO:0048471	perinuclear region of cytoplasm
CC	HDA	GO:0070062	extracellular exosome
BP	IBA	GO:0006511	ubiquitin-dependent protein catabolic process
BP	IEA	GO:0006914	autophagy
BP	NAS	GO:0006954	inflammatory response
BP	IPI	GO:0007165	signal transduction
BP	TAS	GO:0007267	cell-cell signaling
BP	IDA	GO:0016310	phosphorylation
BP	IEP	GO:0030855	epithelial cell differentiation
BP	IEA	GO:0033235	positive regulation of protein sumoylation
BP	NAS	GO:0035556	intracellular signal transduction
BP	IDA	GO:0036010	protein localization to endosome
BP	TAS	GO:0043312	neutrophil degranulation
BP	IEA	GO:0045087	innate immune response
BP	NAS	GO:0045321	leukocyte activation
BP	TAS	GO:0070498	interleukin-1-mediated signaling pathway
MF	IEA	GO:0005150	interleukin-1, type I receptor binding
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0019900	kinase binding
MF	IBA	GO:0031624	ubiquitin conjugating enzyme binding
MF	IEA	GO:0031625	ubiquitin protein ligase binding
MF	IEA	GO:0032183	SUMO binding
MF	IPI	GO:0035325	Toll-like receptor binding
MF	IBA	GO:0043130	ubiquitin binding

Gene expression in normal tissue: TOLLIP

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TOLLIP

Database	Pathway ID	Pathway Des.
wikipathways	WP1449	Regulation of toll-like receptor signaling pathway
wikipathways	WP1772	Apoptosis Modulation and Signaling
wikipathways	WP195	IL-1 signaling pathway
wikipathways	WP2637	Structural Pathway of Interleukin 1 (IL-1)
wikipathways	WP3858	Toll-like Receptor Signaling
wikipathways	WP75	Toll-like Receptor Signaling Pathway
pid	il1pathway	IL1-mediated signaling events
kegg	hsa04620	Toll-like receptor signaling pathway - Homo sapiens (human)
netpath	Pathway_EGFR1	EGFR1
netpath	Pathway_IL1	IL1
biocarta	gsk3pathway	inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocarta	il1rpathway	signal transduction through il1r
biocarta	tollpathway	toll-like receptor pathway
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-446652	Interleukin-1 family signaling
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-6798695	Neutrophil degranulation
reactome	R-HSA-9020702	Interleukin-1 signaling

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD748	PHA-665752	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOLLIP

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