NEURL1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neuralized E3 ubiquitin protein ligase 1 | MIM:603804 | Ensembl:ENSG00000107954 | HGNC:HGNC:7761 | PA31563 | 10q24.33 |
GO terms in NEURL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0030054 | cell junction |
| CC | ISS | GO:0043197 | dendritic spine |
| CC | ISS | GO:0043204 | perikaryon |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | ISS | GO:0097440 | apical dendrite |
| BP | IEA | GO:0006417 | regulation of translation |
| BP | ISS | GO:0006513 | protein monoubiquitination |
| BP | IEA | GO:0007219 | Notch signaling pathway |
| BP | IEA | GO:0007288 | sperm axoneme assembly |
| BP | TAS | GO:0007399 | nervous system development |
| BP | IEA | GO:0007420 | brain development |
| BP | IEA | GO:0007519 | skeletal muscle tissue development |
| BP | IEA | GO:0007595 | lactation |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity |
| BP | IDA | GO:0045746 | negative regulation of Notch signaling pathway |
| BP | ISS | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity |
| BP | ISS | GO:0051491 | positive regulation of filopodium assembly |
| BP | ISS | GO:0060999 | positive regulation of dendritic spine development |
| BP | ISS | GO:0071230 | cellular response to amino acid stimulus |
| BP | ISS | GO:0090129 | positive regulation of synapse maturation |
| MF | ISS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | ISS | GO:0045183 | translation factor activity, non-nucleic acid binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0061630 | ubiquitin protein ligase activity |
Gene expression in normal tissue: NEURL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEURL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | notch_pathway | Notch signaling pathway |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer |
| reactome | R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD68 | Paclitaxel | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEURL1
CLASSFICATION
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