iGMDRD518


Canonical SMILES: CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6

InChI: InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)

InChI Key: LHNIIDJUOCFXAP-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard Name2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine
Pubchem CID17755100
DRUGBANK IDDB11663
Drug StatusAlone
Drug TypeSmall Molecule


Drug Targets:

PI3K (class 1)

Drug Pathways:

PI3K/MTOR signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

2reactome: Signal Transduction2reactome: Signaling by VEGF2reactome: Regulation of signaling by CBL2reactome: Cytokine Signaling in Immune system2reactome: Immune System2reactome: Signaling by Receptor Tyrosine Kinases2reactome: Signaling by NTRKs2reactome: Interleukin-3, Interleukin-5 and GM-CSF signaling2reactome: VEGFA-VEGFR2 Pathway2reactome: Signaling by Interleukins

Drug-gene GO enrichments

3MF: 1-phosphatidylinositol-3-kinase activity2BP: platelet activation2MF: kinase activity2BP: phosphatidylinositol-mediated signaling2CC: phosphatidylinositol 3-kinase complex2BP: phosphatidylinositol phosphorylation2BP: phosphatidylinositol-3-phosphate biosynthetic process2CC: phosphatidylinositol 3-kinase complex, class IA2MF: phosphatidylinositol 3-kinase activity2MF: phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
5290 PIK3CA 1
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Gene in drug-gene network: Network Plot

Models in 2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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