iGMDRD118

Canonical SMILES: CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C

InChI: InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3

InChI Key: SZFPYBIJACMNJV-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NamePerifosine
Pubchem CID148177
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

THYROItissue: THYROI cancer: THYROID model num: 0THYROIDtissue: THYROID cancer: Thyroid Cancer model num: 3

Drug-gene pathway enrichments

3reactome: Signal Transduction3reactome: Immune System2wikipathways: Androgen Receptor Network in Prostate Cancer2wikipathways: Signaling Pathways in Glioblastoma2wikipathways: Focal Adhesion2wikipathways: Signaling of Hepatocyte Growth Factor Receptor2wikipathways: Regulation of Microtubule Cytoskeleton2wikipathways: Copper homeostasis2reactome: PIP3 activates AKT signaling2reactome: PI Metabolism

Drug-gene GO enrichments

3CC: cytoplasm3CC: cytosol3MF: 1-phosphatidylinositol-3-kinase activity2BP: negative regulation of cell proliferation2BP: endothelial cell migration2CC: nucleoplasm2BP: phosphatidylinositol-mediated signaling2BP: negative regulation of phosphatidylinositol 3-kinase signaling2BP: negative regulation of protein kinase B signaling2BP: protein dephosphorylation

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
5290 PIK3CA 2
5728 PTEN 1
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Gene in drug-gene network: Network Plot

cetuximabcetuximabPI3K pathway inhibitors (alone or in combination)PI3K pathway inhibitors (alone or in combination)quinoclaminequinoclaminecytochalasin.Bcytochalasin.BEverolimusEverolimusisoevodiamineisoevodiamineparbendazoleparbendazoletosedostattosedostatoligomycin.Aoligomycin.AML214ML214triptolidetriptolidePI3K pathway inhibitorsPI3K pathway inhibitorsBRD7137BRD7137BYL719 (Alpelisib)BYL719 (Alpelisib)trastuzumab alonetrastuzumab alonePIK3CAPIK3CAMEK inhibitorsMEK inhibitorsLY3023414LY3023414GSK2636771GSK2636771BMS-536924BMS-536924BRD63610BRD63610BIX01294BIX01294VER 155008VER 155008Compound.1541ACompound.1541Abistramide Abistramide APARP inhibitorsPARP inhibitorsmTOR inhibitorsmTOR inhibitorsOlaparibOlaparibMK-2206MK-2206zebularinezebularineAZD8186AZD8186GSK690693GSK690693SirolimusSirolimusPTENPTENPerifosinePerifosine

Models in Perifosine

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
SNV(PIK3CA H1047R) gene 19706758 THYROID Thyroid Cancer Perifosine sensitivity in vivo
SNV(PIK3CA E542K) gene 19706758 THYROID Thyroid Cancer Perifosine sensitivity in vivo
SNV(PTEN R130.) gene 19706758 THYROID Thyroid Cancer Perifosine sensitivity in vivo
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