iGMDRD683


Canonical SMILES: CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C

InChI: InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)

InChI Key: BEUQXVWXFDOSAQ-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameTaselisib
Pubchem CID51001900
DRUGBANK IDDB12108
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

HEAD_NECtissue: HEAD_NEC cancer: HEAD_NECK model num: 0HEAD_NECKtissue: HEAD_NECK cancer: Head and Neck Squamous Cell Carcinoma (HNSC) model num: 4

Drug-gene pathway enrichments

3reactome: Signal Transduction3reactome: Immune System2kegg: Sphingolipid signaling pathway - Homo sapiens (human)2kegg: Phosphatidylinositol signaling system - Homo sapiens (human)2kegg: FoxO signaling pathway - Homo sapiens (human)2kegg: Inositol phosphate metabolism - Homo sapiens (human)2kegg: Autophagy - animal - Homo sapiens (human)2kegg: mTOR signaling pathway - Homo sapiens (human)2kegg: Cellular senescence - Homo sapiens (human)2kegg: PI3K-Akt signaling pathway - Homo sapiens (human)

Drug-gene GO enrichments

3MF: 1-phosphatidylinositol-3-kinase activity3CC: cytosol3CC: cytoplasm2BP: endothelial cell migration2BP: phosphatidylinositol dephosphorylation2BP: protein kinase B signaling2BP: phosphatidylinositol-mediated signaling2BP: cell migration2BP: phosphatidylinositol phosphorylation2BP: phosphatidylinositol-3-phosphate biosynthetic process

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
5290 PIK3CA 3
5728 PTEN 1
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Gene in drug-gene network: Network Plot

Models in Taselisib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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