PLCB4
Summary: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600810 Ensembl IDEnsembl:ENSG00000101333 HGNC IDHGNC:HGNC:9059 PHARMGKB IDPA33387 Map Location20p12.3-p12.2 | |||||
GO terms in PLCB4
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005790 | smooth endoplasmic reticulum |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0030425 | dendrite |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
Gene expression in normal tissue: PLCB4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLCB4
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA161749006 | Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD190 | Nilotinib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLCB4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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