RAET1L
Summary: RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| retinoic acid early transcript 1L | MIM:611047 | Ensembl:ENSG00000155918 | HGNC:HGNC:16798 | PA134918665 | 6q25.1 |
GO terms in RAET1L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0046703 | natural killer cell lectin-like receptor binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0031225 | anchored component of membrane |
| BP | IBA | GO:0001913 | T cell mediated cytotoxicity |
| BP | IBA | GO:0006955 | immune response |
| BP | IEA | GO:0016032 | viral process |
| BP | IBA | GO:0030101 | natural killer cell activation |
| BP | IBA | GO:0042267 | natural killer cell mediated cytotoxicity |
| BP | IBA | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity |
Gene expression in normal tissue: RAET1L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAET1L
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAET1L
CLASSFICATION
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