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MSRA

Summary: This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
methionine sulfoxide reductase A	MIM:601250	Ensembl:ENSG00000175806	HGNC:HGNC:7377	PA31182	8p23.1

GO terms in MSRA

Term Type	Evidence Type	GO Term ID	GO Des.
MF	TAS	GO:0008113	peptide-methionine (S)-S-oxide reductase activity
BP	TAS	GO:0006464	cellular protein modification process
BP	TAS	GO:0006555	methionine metabolic process
BP	TAS	GO:0006979	response to oxidative stress
BP	TAS	GO:0030091	protein repair
BP	IEA	GO:0055114	oxidation-reduction process
CC	IDA	GO:0005654	nucleoplasm
CC	IEA	GO:0005739	mitochondrion
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0015629	actin cytoskeleton
CC	IEA	GO:0016020	membrane
CC	HDA	GO:0070062	extracellular exosome

Gene expression in normal tissue: MSRA

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MSRA

Database	Pathway ID	Pathway Des.
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-5676934	Protein repair
wikipathways	WP2542	Sulindac Metabolic Pathway
wikipathways	WP3580	Methionine De Novo and Salvage Pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD190	Nilotinib	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MSRA

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.