MSRA
Summary: This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601250 Ensembl IDEnsembl:ENSG00000175806 HGNC IDHGNC:HGNC:7377 PHARMGKB IDPA31182 Map Location8p23.1 | |||||
GO terms in MSRA
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | TAS | GO:0006555 | methionine metabolic process |
| BP | TAS | GO:0006979 | response to oxidative stress |
| BP | TAS | GO:0030091 | protein repair |
| BP | IEA | GO:0055114 | oxidation-reduction process |
Gene expression in normal tissue: MSRA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MSRA
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5676934 | Protein repair |
| wikipathways | WP2542 | Sulindac Metabolic Pathway |
| wikipathways | WP3580 | Methionine De Novo and Salvage Pathway |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD190 | Nilotinib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MSRA
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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