CHUK
Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| conserved helix-loop-helix ubiquitous kinase | MIM:600664 | Ensembl:ENSG00000213341 | HGNC:HGNC:1974 | PA26510 | 10q24.31 |
GO terms in CHUK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008384 | IkappaB kinase activity |
| MF | TAS | GO:0008384 | IkappaB kinase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| MF | IDA | GO:0097110 | scaffold protein binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0008385 | IkappaB kinase complex |
| CC | TAS | GO:0008385 | IkappaB kinase complex |
| CC | ISS | GO:0009898 | cytoplasmic side of plasma membrane |
| CC | ISS | GO:0035631 | CD40 receptor complex |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | TAS | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| BP | TAS | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
| BP | IEA | GO:0003009 | skeletal muscle contraction |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | TAS | GO:0006955 | immune response |
| BP | IMP | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0007252 | I-kappaB phosphorylation |
| BP | IEA | GO:0007266 | Rho protein signal transduction |
| BP | TAS | GO:0009615 | response to virus |
| BP | IEA | GO:0009636 | response to toxic substance |
| BP | IBA | GO:0009653 | anatomical structure morphogenesis |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | IEA | GO:0010034 | response to acetate |
| BP | TAS | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0033194 | response to hydroperoxide |
| BP | IBA | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IMP | GO:0034614 | cellular response to reactive oxygen species |
| BP | TAS | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway |
| BP | IMP | GO:0038061 | NIK/NF-kappaB signaling |
| BP | TAS | GO:0038061 | NIK/NF-kappaB signaling |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | IEA | GO:0042493 | response to drug |
| BP | TAS | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043200 | response to amino acid |
| BP | TAS | GO:0045087 | innate immune response |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IBA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0051146 | striated muscle cell differentiation |
| BP | TAS | GO:0051403 | stress-activated MAPK cascade |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IMP | GO:0071276 | cellular response to cadmium ion |
| BP | IDA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IMP | GO:0098586 | cellular response to virus |
| BP | IMP | GO:1902741 | positive regulation of interferon-alpha secretion |
Gene expression in normal tissue: CHUK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHUK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1433 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| wikipathways | WP1434 | Osteopontin Signaling |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP2804 | Hair Follicle Development- Induction (Part 1 of 3) |
| wikipathways | WP288 | NLR Proteins |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3845 | Canonical and Non-canonical Notch signaling |
| wikipathways | WP3849 | MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ |
| wikipathways | WP3858 | Toll-like Receptor Signaling |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP4136 | Fibrin Complement Receptor 3 Signaling Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP712 | Estrogen signaling pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | foxopathway | FoxO family signaling |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | il1pathway | IL1-mediated signaling events |
| pid | nfkappabalternativepathway | Alternative NF-kappaB pathway |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | tnfpathway | TNF receptor signaling pathway |
| pid | toll_endogenous_pathway | Endogenous TLR signaling |
| pid | trail_pathway | TRAIL signaling pathway |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_IL11 | IL11 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_RANKL | RANKL |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TNFalpha | TNFalpha |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
| biocarta | raccycdpathway | influence of ras and rho proteins on g1 to s transition |
| biocarta | ranklpathway | bone remodeling |
| biocarta | raspathway | ras signaling pathway |
| biocarta | rnapathway | double stranded rna induced gene expression |
| biocarta | stresspathway | tnf/stress related signaling |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | tidpathway | chaperones modulate interferon signaling pathway |
| biocarta | tollpathway | toll-like receptor pathway |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1236974 | ER-Phagosome pathway |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-198323 | AKT phosphorylates targets in the cytosol |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-445989 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-5260271 | Diseases of Immune System |
| reactome | R-HSA-5357905 | Regulation of TNFR1 signaling |
| reactome | R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway |
| reactome | R-HSA-5602358 | Diseases associated with the TLR signaling cascade |
| reactome | R-HSA-5602636 | IKBKB deficiency causes SCID |
| reactome | R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) |
| reactome | R-HSA-5603029 | IkBA variant leads to EDA-ID |
| reactome | R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer |
| reactome | R-HSA-5676590 | NIK-->noncanonical NF-kB signaling |
| reactome | R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-933542 | TRAF6 mediated NF-kB activation |
| reactome | R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| reactome | R-HSA-937039 | IRAK1 recruits IKK complex |
| reactome | R-HSA-937041 | IKK complex recruitment mediated by RIP1 |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD560 | MK-2206 | 6 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD433 | Lexibulin | 4 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD888 | Compound 44 | 4 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD270 | Ciclosporin | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHUK
CLASSFICATION
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