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CHUK

Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameconserved helix-loop-helix ubiquitous kinase OMIM IDMIM:600664 Ensembl IDEnsembl:ENSG00000213341 HGNC IDHGNC:HGNC:1974 PHARMGKB IDPA26510 Map Location10q24.31

Gene Categories:

DRUG RESISTANCE DRUGGABLE GENOME KINASE SERINE THREONINE KINASE

GO terms in CHUK

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004672	protein kinase activity
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IBA	GO:0008384	IkappaB kinase activity
MF	TAS	GO:0008384	IkappaB kinase activity

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Gene expression in normal tissue: CHUK

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CHUK

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Database	Pathway ID	Pathway Des.
wikipathways	WP1433	Nucleotide-binding Oligomerization Domain (NOD) pathway
wikipathways	WP1434	Osteopontin Signaling
wikipathways	WP1449	Regulation of toll-like receptor signaling pathway
wikipathways	WP1544	MicroRNAs in cardiomyocyte hypertrophy
wikipathways	WP195	IL-1 signaling pathway
wikipathways	WP2018	RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD154	NSC23766	2
iGMDRD394	BX-795	2
iGMDRD901	ELCPK	1
iGMDRD237	ABT-751	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHUK

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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