CD79A
Summary: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CD79a molecule | MIM:112205 | Ensembl:ENSG00000105369 | HGNC:HGNC:1698 | PA26237 | 19q13.2 |
GO terms in CD79A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | IBA | GO:0030183 | B cell differentiation |
| BP | ISS | GO:0030183 | B cell differentiation |
| BP | ISS | GO:0042100 | B cell proliferation |
| BP | ISS | GO:0042113 | B cell activation |
| BP | IBA | GO:0050853 | B cell receptor signaling pathway |
| BP | ISS | GO:0050853 | B cell receptor signaling pathway |
| BP | IMP | GO:0051289 | protein homotetramerization |
| CC | ISS | GO:0005771 | multivesicular body |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | ISS | GO:0009897 | external side of plasma membrane |
| CC | IBA | GO:0019815 | B cell receptor complex |
| CC | ISS | GO:0019815 | B cell receptor complex |
| CC | ISS | GO:0045121 | membrane raft |
| MF | IEA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: CD79A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD79A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5690714 | CD22 mediated BCR regulation |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | ctcfpathway | ctcf: first multivalent nuclear factor |
| pid | bcr_5pathway | BCR signaling pathway |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05340 | Primary immunodeficiency - Homo sapiens (human) |
| netpath | Pathway_BCR | BCR |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD330 | BRD4132 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD79A
CLASSFICATION
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