OR4E2


Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
olfactory receptor family 4 subfamily E member 2Ensembl:ENSG00000221977HGNC:HGNC:8297PA3227814q11.2

GO terms in OR4E2


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0050911detection of chemical stimulus involved in sensory perception of smell
CCTASGO:0005886plasma membrane
MFIBAGO:0004888transmembrane signaling receptor activity
MFIEAGO:0004930G-protein coupled receptor activity
MFIEAGO:0004984olfactory receptor activity

Gene expression in normal tissue: OR4E2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in OR4E2


DatabasePathway IDPathway Des.
kegghsa04740Olfactory transduction - Homo sapiens (human)
wikipathwaysWP3608Olfactory receptor activity

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD77Itraconazole3
iGMDRD670ML 2102
iGMDRD137Indisulam4
iGMDRD202Curcumin6
iGMDRD138PX 123
iGMDRD433Lexibulin3
iGMDRD64Parbendazole3
iGMDRD123Isoevodiamine3
iGMDRD399Selumetinib3
iGMDRD446LY 21832403
iGMDRD341Triacsin c2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in OR4E2

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