PIP4K2B

Summary: The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namephosphatidylinositol-5-phosphate 4-kinase type 2 beta
OMIM IDMIM:603261
Ensembl IDEnsembl:ENSG00000276293
HGNC IDHGNC:HGNC:8998
PHARMGKB IDPA162399640
Map Location17q12

Gene Categories:

DRUGGABLE GENOMEKINASE

GO terms in PIP4K2B


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IDA GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
MF EXP GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity
MF TAS GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity
MF IDA GO:0042803 protein homodimerization activity
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Gene expression in normal tissue: PIP4K2B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIP4K2B


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Database
Pathway ID
Pathway Des.
kegg hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
kegg hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
kegg hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
netpath Pathway_BCR BCR
humancyc PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
humancyc PWY-6352 3-phosphoinositide biosynthesis
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD446 LY 2183240 3
iGMDRD341 Triacsin c 3
iGMDRD399 Selumetinib 3
iGMDRD394 BX-795 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIP4K2B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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