PIP4K2B
Summary: The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol-5-phosphate 4-kinase type 2 beta | MIM:603261 | Ensembl:ENSG00000276293 | HGNC:HGNC:8998 | PA162399640 | 17q12 |
GO terms in PIP4K2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| MF | EXP | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| MF | TAS | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | TAS | GO:0052811 | 1-phosphatidylinositol-3-phosphate 4-kinase activity |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IMP | GO:0005776 | autophagosome |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| BP | TAS | GO:0006644 | phospholipid metabolic process |
| BP | TAS | GO:0006661 | phosphatidylinositol biosynthetic process |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IMP | GO:0010506 | regulation of autophagy |
| BP | TAS | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IMP | GO:2000786 | positive regulation of autophagosome assembly |
Gene expression in normal tissue: PIP4K2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIP4K2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| netpath | Pathway_BCR | BCR |
| humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| humancyc | PWY-6352 | 3-phosphoinositide biosynthesis |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1660499 | Synthesis of PIPs at the plasma membrane |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6804758 | Regulation of TP53 Activity through Acetylation |
| reactome | R-HSA-6811555 | PI5P Regulates TP53 Acetylation |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8847453 | Synthesis of PIPs in the nucleus |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD105 | Triptolide | 6 |
| iGMDRD560 | MK-2206 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIP4K2B
CLASSFICATION
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