Summary: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

TGF-beta activated kinase 1 (MAP3K7) binding protein 2MIM:605101Ensembl:ENSG00000228408HGNC:HGNC:17075PA306056q25.1

GO terms in TAB2

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCTASGO:0010008endosome membrane
BPTASGO:0000187activation of MAPK activity
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPTASGO:0002755MyD88-dependent toll-like receptor signaling pathway
BPTASGO:0007249I-kappaB kinase/NF-kappaB signaling
BPTASGO:0007254JNK cascade
BPIMPGO:0007507heart development
BPTASGO:0010507negative regulation of autophagy
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPIEPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0045860positive regulation of protein kinase activity
BPTASGO:0050852T cell receptor signaling pathway
BPTASGO:0051092positive regulation of NF-kappaB transcription factor activity
BPTASGO:0070423nucleotide-binding oligomerization domain containing signaling pathway
BPTASGO:0070498interleukin-1-mediated signaling pathway
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
MFIDAGO:0070530K63-linked polyubiquitin modification-dependent protein binding

Gene expression in normal tissue: TAB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TAB2

DatabasePathway IDPathway Des.
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3851TLR4 Signaling and Tolerance
wikipathwaysWP410Exercise-induced Circadian Regulation
wikipathwaysWP75Toll-like Receptor Signaling Pathway
pidbmppathwayBMP receptor signaling
pidcmyb_pathwayC-MYB transcription factor network
piderbb4_pathwayErbB4 signaling events
pidil1pathwayIL1-mediated signaling events
pidp38_mkk3_6pathwayp38 MAPK signaling pathway
pidtgfbrpathwayTGF-beta receptor signaling
pidtnfpathwayTNF receptor signaling pathway
pidwnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
biocartail1rpathwaysignal transduction through il1r
biocartatollpathwaytoll-like receptor pathway
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1251985Nuclear signaling by ERBB4
reactomeR-HSA-1251985Nuclear signaling by ERBB4
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complex
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-450302activated TAK1 mediates p38 MAPK activation
reactomeR-HSA-450321JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
reactomeR-HSA-5357956TNFR1-induced NFkappaB signaling pathway
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75893TNF signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9014325TICAM1,TRAF6-dependent induction of TAK1 complex
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-937042IRAK2 mediated activation of TAK1 complex
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-937072TRAF6-mediated induction of TAK1 complex within TLR4 complex
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975163IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD441TW 371
iGMDRD5Tyrphostin AG 14783
iGMDRD679Bistramide A3
iGMDRD61Kinetin riboside3
iGMDRD71Sparfosic acid3
iGMDRD85Ursolic acid1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TAB2