GATA1

Summary: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameGATA binding protein 1
OMIM IDMIM:305371
Ensembl IDEnsembl:ENSG00000102145
HGNC IDHGNC:HGNC:4170
PHARMGKB IDPA28584
Map LocationXp11.23

GO terms in GATA1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0000122 negative regulation of transcription by RNA polymerase II
BP IEA GO:0001701 in utero embryonic development
BP IDA GO:0006366 transcription by RNA polymerase II
BP IEA GO:0007267 cell-cell signaling
BP IBA GO:0007507 heart development
BP TAS GO:0007596 blood coagulation
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Gene expression in normal tissue: GATA1

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 8undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 21

Gene-drug pathway distribution

undefined7Chromatin histone acetylation1PI3K/MTOR signaling1

Pathways in GATA1


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Database
Pathway ID
Pathway Des.
wikipathways WP2849 Hematopoietic Stem Cell Differentiation
pid cmyb_pathway C-MYB transcription factor network
pid hdac_classi_pathway Signaling events mediated by HDAC Class I
pid hdac_classii_pathway Signaling events mediated by HDAC Class II
pid hes_heypathway Notch-mediated HES/HEY network
pid p73pathway p73 transcription factor network
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD394 BX-795 1
iGMDRD147 Prima-1 3
iGMDRD366 PI-103 5
iGMDRD85 Ursolic acid 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GATA1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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