GATA1


Summary: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
GATA binding protein 1MIM:305371Ensembl:ENSG00000102145HGNC:HGNC:4170PA28584Xp11.23

GO terms in GATA1


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001701in utero embryonic development
BPIDAGO:0006366transcription by RNA polymerase II
BPIEAGO:0007267cell-cell signaling
BPIBAGO:0007507heart development
BPTASGO:0007596blood coagulation
BPIEAGO:0008285negative regulation of cell proliferation
BPIMPGO:0008584male gonad development
BPIBAGO:0009887animal organ morphogenesis
BPIBAGO:0009888tissue development
BPIMPGO:0010559regulation of glycoprotein biosynthetic process
BPIDAGO:0010724regulation of definitive erythrocyte differentiation
BPIEAGO:0010725regulation of primitive erythrocyte differentiation
BPIEPGO:0030218erythrocyte differentiation
BPIMPGO:0030219megakaryocyte differentiation
BPIMPGO:0030220platelet formation
BPIEPGO:0030221basophil differentiation
BPIEPGO:0030222eosinophil differentiation
BPIEAGO:0030502negative regulation of bone mineralization
BPIEAGO:0033690positive regulation of osteoblast proliferation
BPIEAGO:0035162embryonic hemopoiesis
BPIDAGO:0035854eosinophil fate commitment
BPIMPGO:0043066negative regulation of apoptotic process
BPIBAGO:0045165cell fate commitment
BPIMPGO:0045648positive regulation of erythrocyte differentiation
BPTASGO:0045652regulation of megakaryocyte differentiation
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIBAGO:0048468cell development
BPIBAGO:0048565digestive tract development
BPIBAGO:0048646anatomical structure formation involved in morphogenesis
BPIMPGO:0048821erythrocyte development
BPIEAGO:0048873homeostasis of number of cells within a tissue
BPIMPGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIMPGO:0070527platelet aggregation
BPISSGO:0071733transcriptional activation by promoter-enhancer looping
BPIEAGO:0097028dendritic cell differentiation
BPIDAGO:0097067cellular response to thyroid hormone stimulus
BPTASGO:1902036regulation of hematopoietic stem cell differentiation
BPIDAGO:2000678negative regulation of transcription regulatory region DNA binding
BPIMPGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005667transcription factor complex
CCIDAGO:0017053transcriptional repressor complex
CCIDAGO:0032993protein-DNA complex
MFIMPGO:0000976transcription regulatory region sequence-specific DNA binding
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIBAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIMPGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001076transcription factor activity, RNA polymerase II transcription factor binding
MFIBAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIPIGO:0001085RNA polymerase II transcription factor binding
MFIEAGO:0002039p53 binding
MFIDAGO:0003677DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIEAGO:0008301DNA binding, bending
MFIDAGO:0031490chromatin DNA binding
MFIMPGO:0043565sequence-specific DNA binding
MFIPIGO:0070742C2H2 zinc finger domain binding

Gene expression in normal tissue: GATA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GATA1


DatabasePathway IDPathway Des.
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation
pidcmyb_pathwayC-MYB transcription factor network
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidhdac_classii_pathwaySignaling events mediated by HDAC Class II
pidhes_heypathwayNotch-mediated HES/HEY network
pidp73pathwayp73 transcription factor network
biocartaahsppathwayhemoglobins chaperone
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
reactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCs
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD394BX-7951
iGMDRD147Prima-13
iGMDRD366PI-1035
iGMDRD85Ursolic acid3
iGMDRD341Triacsin c4
iGMDRD289Parthenolide3
iGMDRD5Tyrphostin AG 14783
iGMDRD599Salermide6
iGMDRD330BRD41321

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GATA1

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