GATA1
Summary: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| GATA binding protein 1 | MIM:305371 | Ensembl:ENSG00000102145 | HGNC:HGNC:4170 | PA28584 | Xp11.23 |
GO terms in GATA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IDA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007267 | cell-cell signaling |
| BP | IBA | GO:0007507 | heart development |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IMP | GO:0008584 | male gonad development |
| BP | IBA | GO:0009887 | animal organ morphogenesis |
| BP | IBA | GO:0009888 | tissue development |
| BP | IMP | GO:0010559 | regulation of glycoprotein biosynthetic process |
| BP | IDA | GO:0010724 | regulation of definitive erythrocyte differentiation |
| BP | IEA | GO:0010725 | regulation of primitive erythrocyte differentiation |
| BP | IEP | GO:0030218 | erythrocyte differentiation |
| BP | IMP | GO:0030219 | megakaryocyte differentiation |
| BP | IMP | GO:0030220 | platelet formation |
| BP | IEP | GO:0030221 | basophil differentiation |
| BP | IEP | GO:0030222 | eosinophil differentiation |
| BP | IEA | GO:0030502 | negative regulation of bone mineralization |
| BP | IEA | GO:0033690 | positive regulation of osteoblast proliferation |
| BP | IEA | GO:0035162 | embryonic hemopoiesis |
| BP | IDA | GO:0035854 | eosinophil fate commitment |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0045165 | cell fate commitment |
| BP | IMP | GO:0045648 | positive regulation of erythrocyte differentiation |
| BP | TAS | GO:0045652 | regulation of megakaryocyte differentiation |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0048468 | cell development |
| BP | IBA | GO:0048565 | digestive tract development |
| BP | IBA | GO:0048646 | anatomical structure formation involved in morphogenesis |
| BP | IMP | GO:0048821 | erythrocyte development |
| BP | IEA | GO:0048873 | homeostasis of number of cells within a tissue |
| BP | IMP | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0070527 | platelet aggregation |
| BP | ISS | GO:0071733 | transcriptional activation by promoter-enhancer looping |
| BP | IEA | GO:0097028 | dendritic cell differentiation |
| BP | IDA | GO:0097067 | cellular response to thyroid hormone stimulus |
| BP | TAS | GO:1902036 | regulation of hematopoietic stem cell differentiation |
| BP | IDA | GO:2000678 | negative regulation of transcription regulatory region DNA binding |
| BP | IMP | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0017053 | transcriptional repressor complex |
| CC | IDA | GO:0032993 | protein-DNA complex |
| MF | IMP | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IMP | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding |
| MF | IBA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0001085 | RNA polymerase II transcription factor binding |
| MF | IEA | GO:0002039 | p53 binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0008301 | DNA binding, bending |
| MF | IDA | GO:0031490 | chromatin DNA binding |
| MF | IMP | GO:0043565 | sequence-specific DNA binding |
| MF | IPI | GO:0070742 | C2H2 zinc finger domain binding |
Gene expression in normal tissue: GATA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GATA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | p73pathway | p73 transcription factor network |
| biocarta | ahsppathway | hemoglobins chaperone |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| reactome | R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD394 | BX-795 | 1 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD366 | PI-103 | 5 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD341 | Triacsin c | 4 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD599 | Salermide | 6 |
| iGMDRD330 | BRD4132 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GATA1
CLASSFICATION
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