MAPK14
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase 14 | MIM:600289 | Ensembl:ENSG00000112062 | HGNC:HGNC:6876 | PA30621 | 6p21.31 |
GO terms in MAPK14
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004707 | MAP kinase activity |
| MF | IDA | GO:0004707 | MAP kinase activity |
| MF | TAS | GO:0004708 | MAP kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IPI | GO:0048273 | mitogen-activated protein kinase p38 binding |
| MF | ISS | GO:0051525 | NFAT protein binding |
| CC | IEA | GO:0000922 | spindle pole |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| BP | IEA | GO:0000077 | DNA damage checkpoint |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0000902 | cell morphogenesis |
| BP | IEA | GO:0001502 | cartilage condensation |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001890 | placenta development |
| BP | IEA | GO:0002062 | chondrocyte differentiation |
| BP | IEA | GO:0002741 | positive regulation of cytokine secretion involved in immune response |
| BP | IEA | GO:0006006 | glucose metabolic process |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | ISS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006935 | chemotaxis |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IEA | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| BP | IEA | GO:0007519 | skeletal muscle tissue development |
| BP | IBA | GO:0010468 | regulation of gene expression |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0010759 | positive regulation of macrophage chemotaxis |
| BP | ISS | GO:0010831 | positive regulation of myotube differentiation |
| BP | IEA | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration |
| BP | ISS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0019395 | fatty acid oxidation |
| BP | IEA | GO:0030278 | regulation of ossification |
| BP | ISS | GO:0030316 | osteoclast differentiation |
| BP | IMP | GO:0031281 | positive regulation of cyclase activity |
| BP | IEA | GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| BP | IEA | GO:0032495 | response to muramyl dipeptide |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IEA | GO:0035994 | response to muscle stretch |
| BP | ISS | GO:0038066 | p38MAPK cascade |
| BP | IEA | GO:0042307 | positive regulation of protein import into nucleus |
| BP | IMP | GO:0042770 | signal transduction in response to DNA damage |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IMP | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IMP | GO:0045648 | positive regulation of erythrocyte differentiation |
| BP | ISS | GO:0045663 | positive regulation of myoblast differentiation |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046326 | positive regulation of glucose import |
| BP | IMP | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IEA | GO:0051146 | striated muscle cell differentiation |
| BP | TAS | GO:0051149 | positive regulation of muscle cell differentiation |
| BP | IEA | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| BP | TAS | GO:0070935 | 3'-UTR-mediated mRNA stabilization |
| BP | IDA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IMP | GO:0071223 | cellular response to lipoteichoic acid |
| BP | IBA | GO:0071310 | cellular response to organic substance |
| BP | IEA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IMP | GO:0071479 | cellular response to ionizing radiation |
| BP | IEA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0090336 | positive regulation of brown fat cell differentiation |
| BP | IMP | GO:0090400 | stress-induced premature senescence |
| BP | IMP | GO:0098586 | cellular response to virus |
| BP | IDA | GO:1900015 | regulation of cytokine production involved in inflammatory response |
| BP | ISS | GO:1901741 | positive regulation of myoblast fusion |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| BP | IEA | GO:1905050 | positive regulation of metallopeptidase activity |
| BP | IMP | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| BP | IMP | GO:2001184 | positive regulation of interleukin-12 secretion |
Gene expression in normal tissue: MAPK14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAPK14
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP2447 | Amyotrophic lateral sclerosis (ALS) |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3668 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP3874 | Canonical and Non-Canonical TGF-B signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP408 | Oxidative Stress |
| wikipathways | WP422 | MAPK Cascade |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP712 | Estrogen signaling pathway |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| wikipathways | WP727 | Monoamine Transport |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | cxcr3pathway | CXCR3-mediated signaling events |
| pid | endothelinpathway | Endothelins |
| pid | epopathway | EPO signaling pathway |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | fgf_pathway | FGF signaling pathway |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| pid | p38_mk2pathway | p38 signaling mediated by MAPKAP kinases |
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| pid | p53regulationpathway | p53 pathway |
| pid | p73pathway | p73 transcription factor network |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | rapid_gr_pathway | Rapid glucocorticoid signaling |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | s1p_s1p2_pathway | S1P2 pathway |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| biocarta | 41bbpathway | the 41bb-dependent immune response |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | dsppathway | regulation of map kinase pathways through dual specificity phosphatases |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | gata3pathway | gata3 participate in activating the th2 cytokine genes expression |
| biocarta | hcmvpathway | human cytomegalovirus and map kinase pathways |
| biocarta | hdacpathway | control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) |
| biocarta | il10pathway | il-10 anti-inflammatory signaling pathway |
| biocarta | il12pathway | il12 and stat4 dependent signaling pathway in th1 development |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | smrtepathway | map kinase inactivation of smrt corepressor |
| biocarta | stresspathway | tnf/stress related signaling |
| biocarta | tollpathway | toll-like receptor pathway |
| biocarta | tsp1pathway | tsp-1 induced apoptosis in microvascular endothelial cell |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-171007 | p38MAPK events |
| reactome | R-HSA-171007 | p38MAPK events |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-198753 | ERK/MAPK targets |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-376172 | DSCAM interactions |
| reactome | R-HSA-392518 | Signal amplification |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-432142 | Platelet sensitization by LDL |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450302 | activated TAK1 mediates p38 MAPK activation |
| reactome | R-HSA-450341 | Activation of the AP-1 family of transcription factors |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA |
| reactome | R-HSA-525793 | Myogenesis |
| reactome | R-HSA-525793 | Myogenesis |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_RANKL | RANKL |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_TSLP | TSLP |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD484 | Pluripotin | 6 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD398 | Sepantronium | 6 |
| iGMDRD414 | MST-312 | 9 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD399 | Selumetinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAPK14
CLASSFICATION
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