TCL1A
Summary: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| T cell leukemia/lymphoma 1A | MIM:186960 | Ensembl:ENSG00000100721 | HGNC:HGNC:11648 | PA36400 | 14q32.13 |
GO terms in TCL1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IMP | GO:0043539 | protein serine/threonine kinase activator activity |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0010918 | positive regulation of mitochondrial membrane potential |
| BP | IDA | GO:0032461 | positive regulation of protein oligomerization |
| BP | IMP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0070207 | protein homotrimerization |
| BP | IDA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IDA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IMP | GO:0032991 | protein-containing complex |
Gene expression in normal tissue: TCL1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TCL1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_BCR | BCR |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD147 | Prima-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TCL1A
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