NLRP10
Summary: Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NLR family pyrin domain containing 10 | MIM:609662 | Ensembl:ENSG00000182261 | HGNC:HGNC:21464 | PA162397832 | 11p15.4 |
GO terms in NLRP10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | ISS | GO:0002827 | positive regulation of T-helper 1 type immune response |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IBA | GO:0009617 | response to bacterium |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IMP | GO:0050717 | positive regulation of interleukin-1 alpha secretion |
| BP | ISS | GO:0050729 | positive regulation of inflammatory response |
| BP | IMP | GO:0050829 | defense response to Gram-negative bacterium |
| BP | ISS | GO:0050832 | defense response to fungus |
| BP | IMP | GO:1900426 | positive regulation of defense response to bacterium |
| BP | ISS | GO:2000318 | positive regulation of T-helper 17 type immune response |
| BP | IMP | GO:2000484 | positive regulation of interleukin-8 secretion |
| BP | IMP | GO:2000778 | positive regulation of interleukin-6 secretion |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0019897 | extrinsic component of plasma membrane |
| MF | IDA | GO:0003924 | GTPase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016887 | ATPase activity |
Gene expression in normal tissue: NLRP10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NLRP10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1433 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD61 | Kinetin riboside | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NLRP10
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