NLRP10


Summary: Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
NLR family pyrin domain containing 10MIM:609662Ensembl:ENSG00000182261HGNC:HGNC:21464PA16239783211p15.4

GO terms in NLRP10


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0002250adaptive immune response
BPISSGO:0002827positive regulation of T-helper 1 type immune response
BPIEAGO:0006954inflammatory response
BPIBAGO:0009617response to bacterium
BPIEAGO:0045087innate immune response
BPIMPGO:0050717positive regulation of interleukin-1 alpha secretion
BPISSGO:0050729positive regulation of inflammatory response
BPIMPGO:0050829defense response to Gram-negative bacterium
BPISSGO:0050832defense response to fungus
BPIMPGO:1900426positive regulation of defense response to bacterium
BPISSGO:2000318positive regulation of T-helper 17 type immune response
BPIMPGO:2000484positive regulation of interleukin-8 secretion
BPIMPGO:2000778positive regulation of interleukin-6 secretion
CCIDAGO:0005737cytoplasm
CCIDAGO:0019897extrinsic component of plasma membrane
MFIDAGO:0003924GTPase activity
MFIEAGO:0005524ATP binding
MFIDAGO:0016887ATPase activity

Gene expression in normal tissue: NLRP10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NLRP10


DatabasePathway IDPathway Des.
wikipathwaysWP1433Nucleotide-binding Oligomerization Domain (NOD) pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD512nutlin 33
iGMDRD599Salermide3
iGMDRD483SCH-5290743
iGMDRD870BRD636103
iGMDRD871BRD63683
iGMDRD367Ro 28-16753
iGMDRD872BRD71373
iGMDRD85Ursolic acid3
iGMDRD61Kinetin riboside6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NLRP10

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