TOX


Summary: The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
thymocyte selection associated high mobility group boxMIM:606863Ensembl:ENSG00000198846HGNC:HGNC:18988PA1624067048q12.1

GO terms in TOX


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
CCIEAGO:0005634nucleus
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0030098lymphocyte differentiation
BPIEAGO:0032825positive regulation of natural killer cell differentiation
BPIEAGO:0048535lymph node development
BPIEAGO:0048541Peyer's patch development

Gene expression in normal tissue: TOX

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TOX


DatabasePathway IDPathway Des.
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP3893Development and heterogeneity of the ILC family

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD560MK-22063
iGMDRD210AC556491
iGMDRD512nutlin 32
iGMDRD123Isoevodiamine2
iGMDRD280CYTOCHALASIN B3
iGMDRD901ELCPK2
iGMDRD297Austocystin D3
iGMDRD85Ursolic acid2
iGMDRD446LY 21832403
iGMDRD193Fqi12
iGMDRD782DC-45-A22
iGMDRD318PAC-15
iGMDRD226ML0062
iGMDRD137Indisulam2
iGMDRD121GMX17782
iGMDRD60Quinoclamine5
iGMDRD64Parbendazole5
iGMDRD353PD03259012
iGMDRD871BRD63685
iGMDRD888Compound 446
iGMDRD577BIX012943

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOX

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