TOX
Summary: The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| thymocyte selection associated high mobility group box | MIM:606863 | Ensembl:ENSG00000198846 | HGNC:HGNC:18988 | PA162406704 | 8q12.1 |
GO terms in TOX
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| CC | IEA | GO:0005634 | nucleus |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0030098 | lymphocyte differentiation |
| BP | IEA | GO:0032825 | positive regulation of natural killer cell differentiation |
| BP | IEA | GO:0048535 | lymph node development |
| BP | IEA | GO:0048541 | Peyer's patch development |
Gene expression in normal tissue: TOX
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TOX
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3893 | Development and heterogeneity of the ILC family |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD888 | Compound 44 | 6 |
| iGMDRD577 | BIX01294 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TOX
CLASSFICATION
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