APOBEC3H
Summary: This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:610976 Ensembl IDEnsembl:ENSG00000100298 HGNC IDHGNC:HGNC:24100 PHARMGKB IDPA162376694 Map Location22q13.1 | |||||
GO terms in APOBEC3H
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003723 | RNA binding |
| MF | IBA | GO:0004126 | cytidine deaminase activity |
| MF | IDA | GO:0004126 | cytidine deaminase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| CC | IDA | GO:0000932 | P-body |
Gene expression in normal tissue: APOBEC3H
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APOBEC3H
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-72200 | mRNA Editing: C to U Conversion |
| reactome | R-HSA-75072 | mRNA Editing |
| reactome | R-HSA-75094 | Formation of the Editosome |
| reactome | R-HSA-8953854 | Metabolism of RNA |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in APOBEC3H
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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