APOBEC3H
Summary: This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| apolipoprotein B mRNA editing enzyme catalytic subunit 3H | MIM:610976 | Ensembl:ENSG00000100298 | HGNC:HGNC:24100 | PA162376694 | 22q13.1 |
GO terms in APOBEC3H
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003723 | RNA binding |
| MF | IBA | GO:0004126 | cytidine deaminase activity |
| MF | IDA | GO:0004126 | cytidine deaminase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| CC | IDA | GO:0000932 | P-body |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| BP | IEA | GO:0009972 | cytidine deamination |
| BP | IDA | GO:0010529 | negative regulation of transposition |
| BP | IMP | GO:0010529 | negative regulation of transposition |
| BP | IBA | GO:0016554 | cytidine to uridine editing |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IDA | GO:0045869 | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate |
| BP | IMP | GO:0048525 | negative regulation of viral process |
| BP | IDA | GO:0051607 | defense response to virus |
| BP | IDA | GO:0070383 | DNA cytosine deamination |
| BP | IBA | GO:0080111 | DNA demethylation |
Gene expression in normal tissue: APOBEC3H
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APOBEC3H
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-72200 | mRNA Editing: C to U Conversion |
| reactome | R-HSA-75072 | mRNA Editing |
| reactome | R-HSA-75094 | Formation of the Editosome |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in APOBEC3H
CLASSFICATION
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