PLK1

Summary: The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namepolo like kinase 1
OMIM IDMIM:602098
Ensembl IDEnsembl:ENSG00000166851
HGNC IDHGNC:HGNC:9077
PHARMGKB IDPA33410
Map Location16p12.2

GO terms in PLK1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IMP GO:0000070 mitotic sister chromatid segregation
BP IDA GO:0000086 G2/M transition of mitotic cell cycle
BP TAS GO:0000086 G2/M transition of mitotic cell cycle
BP IMP GO:0000122 negative regulation of transcription by RNA polymerase II
BP IDA GO:0000278 mitotic cell cycle
BP IMP GO:0000278 mitotic cell cycle
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Gene expression in normal tissue: PLK1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLK1


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Database
Pathway ID
Pathway Des.
kegg hsa04068 FoxO signaling pathway - Homo sapiens (human)
kegg hsa04110 Cell cycle - Homo sapiens (human)
kegg hsa04114 Oocyte meiosis - Homo sapiens (human)
kegg hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
pid atr_pathway ATR signaling pathway
pid foxm1pathway FOXM1 transcription factor network
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD546 BMS-754807 3
iGMDRD705 Nakiterpiosin 3
iGMDRD512 nutlin 3 4
iGMDRD121 GMX1778 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLK1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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