PLK1
Summary: The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| polo like kinase 1 | MIM:602098 | Ensembl:ENSG00000166851 | HGNC:HGNC:9077 | PA33410 | 16p12.2 |
GO terms in PLK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000070 | mitotic sister chromatid segregation |
| BP | IDA | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000278 | mitotic cell cycle |
| BP | IMP | GO:0000278 | mitotic cell cycle |
| BP | IDA | GO:0000281 | mitotic cytokinesis |
| BP | IDA | GO:0001578 | microtubule bundle formation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007062 | sister chromatid cohesion |
| BP | TAS | GO:0007077 | mitotic nuclear envelope disassembly |
| BP | IMP | GO:0007094 | mitotic spindle assembly checkpoint |
| BP | IMP | GO:0007098 | centrosome cycle |
| BP | IMP | GO:0007346 | regulation of mitotic cell cycle |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IMP | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation |
| BP | IEA | GO:0016321 | female meiosis chromosome segregation |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0030071 | regulation of mitotic metaphase/anaphase transition |
| BP | TAS | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | IDA | GO:0031648 | protein destabilization |
| BP | IMP | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0032465 | regulation of cytokinesis |
| BP | IMP | GO:0032465 | regulation of cytokinesis |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0043393 | regulation of protein binding |
| BP | IEA | GO:0045143 | homologous chromosome segregation |
| BP | IMP | GO:0045184 | establishment of protein localization |
| BP | IMP | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IDA | GO:0045862 | positive regulation of proteolysis |
| BP | IMP | GO:0051081 | nuclear envelope disassembly |
| BP | IMP | GO:0051443 | positive regulation of ubiquitin-protein transferase activity |
| BP | TAS | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:0070194 | synaptonemal complex disassembly |
| BP | IDA | GO:0071168 | protein localization to chromatin |
| BP | IDA | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint |
| BP | IMP | GO:0090435 | protein localization to nuclear envelope |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | TAS | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | IDA | GO:1901673 | regulation of mitotic spindle assembly |
| BP | TAS | GO:1902749 | regulation of cell cycle G2/M phase transition |
| BP | IDA | GO:1904668 | positive regulation of ubiquitin protein ligase activity |
| BP | TAS | GO:1904668 | positive regulation of ubiquitin protein ligase activity |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IEA | GO:0000785 | chromatin |
| CC | IEA | GO:0000795 | synaptonemal complex |
| CC | IDA | GO:0000922 | spindle pole |
| CC | IDA | GO:0000942 | condensed nuclear chromosome outer kinetochore |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005819 | spindle |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005876 | spindle microtubule |
| CC | IDA | GO:0015630 | microtubule cytoskeleton |
| CC | IDA | GO:0030496 | midbody |
| CC | IDA | GO:0051233 | spindle midzone |
| MF | IMP | GO:0000287 | magnesium ion binding |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IMP | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IMP | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0005524 | ATP binding |
| MF | IDA | GO:0008017 | microtubule binding |
| MF | IPI | GO:0010997 | anaphase-promoting complex binding |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: PLK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| pid | atr_pathway | ATR signaling pathway |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | foxopathway | FoxO family signaling |
| pid | p73pathway | p73 transcription factor network |
| pid | plk1_pathway | PLK1 signaling events |
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1859 | Mitotic G2-G2-M phases |
| wikipathways | WP1971 | Integrated Cancer Pathway |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-156711 | Polo-like kinase mediated events |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization |
| reactome | R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| reactome | R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase |
| reactome | R-HSA-176412 | Phosphorylation of the APC/C |
| reactome | R-HSA-176417 | Phosphorylation of Emi1 |
| reactome | R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2299718 | Condensation of Prophase Chromosomes |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68881 | Mitotic Metaphase/Anaphase Transition |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68884 | Mitotic Telophase/Cytokinesis |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD100 | Zebularine | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLK1
CLASSFICATION
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