SH3GL1


Summary: This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SH3 domain containing GRB2 like 1, endophilin A2MIM:601768Ensembl:ENSG00000141985HGNC:HGNC:10830PA3573619p13.3

GO terms in SH3GL1


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0002102podosome
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCIEAGO:0030054cell junction
CCIEAGO:0031901early endosome membrane
CCIEAGO:0042995cell projection
CCIEAGO:0098686hippocampal mossy fiber to CA3 synapse
BPTASGO:0007165signal transduction
BPTASGO:0007417central nervous system development
BPIEAGO:0016191synaptic vesicle uncoating
BPIEAGO:0098815modulation of excitatory postsynaptic potential
BPIEAGO:1900244positive regulation of synaptic vesicle endocytosis
MFIPIGO:0005515protein binding
MFIEAGO:0008022protein C-terminus binding
MFIEAGO:0008289lipid binding
MFIEAGO:0017124SH3 domain binding
MFIEAGO:0019902phosphatase binding
MFIEAGO:0031697beta-1 adrenergic receptor binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0044325ion channel binding
MFHDAGO:0045296cadherin binding
MFIEAGO:0051020GTPase binding

Gene expression in normal tissue: SH3GL1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SH3GL1


DatabasePathway IDPathway Des.
pidfak_pathwaySignaling events mediated by focal adhesion kinase
kegghsa04144Endocytosis - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-182971EGFR downregulation
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-6807004Negative regulation of MET activity
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis
reactomeR-HSA-8875360InlB-mediated entry of Listeria monocytogenes into host cell
reactomeR-HSA-8876384Listeria monocytogenes entry into host cells
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD945ML2143
iGMDRD451Serdemetan3
iGMDRD300Tozasertib3
iGMDRD280CYTOCHALASIN B1
iGMDRD123Isoevodiamine3
iGMDRD314Tanespimycin3
iGMDRD414MST-3123
iGMDRD871BRD63683
iGMDRD872BRD71373
iGMDRD289Parthenolide1
iGMDRD512nutlin 33
iGMDRD248BRD43543

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SH3GL1

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