SH3GL1
Summary: This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SH3 domain containing GRB2 like 1, endophilin A2 | MIM:601768 | Ensembl:ENSG00000141985 | HGNC:HGNC:10830 | PA35736 | 19p13.3 |
GO terms in SH3GL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0002102 | podosome |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0031901 | early endosome membrane |
| CC | IEA | GO:0042995 | cell projection |
| CC | IEA | GO:0098686 | hippocampal mossy fiber to CA3 synapse |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007417 | central nervous system development |
| BP | IEA | GO:0016191 | synaptic vesicle uncoating |
| BP | IEA | GO:0098815 | modulation of excitatory postsynaptic potential |
| BP | IEA | GO:1900244 | positive regulation of synaptic vesicle endocytosis |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008022 | protein C-terminus binding |
| MF | IEA | GO:0008289 | lipid binding |
| MF | IEA | GO:0017124 | SH3 domain binding |
| MF | IEA | GO:0019902 | phosphatase binding |
| MF | IEA | GO:0031697 | beta-1 adrenergic receptor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0044325 | ion channel binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0051020 | GTPase binding |
Gene expression in normal tissue: SH3GL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SH3GL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-6807004 | Negative regulation of MET activity |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell |
| reactome | R-HSA-8876384 | Listeria monocytogenes entry into host cells |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD248 | BRD4354 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SH3GL1
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