SH3GL1

Summary: This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSH3 domain containing GRB2 like 1, endophilin A2
OMIM IDMIM:601768
Ensembl IDEnsembl:ENSG00000141985
HGNC IDHGNC:HGNC:10830
PHARMGKB IDPA35736
Map Location19p13.3

GO terms in SH3GL1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0002102 podosome
CC IDA GO:0005737 cytoplasm
CC IDA GO:0005829 cytosol
CC IEA GO:0030054 cell junction
CC IEA GO:0031901 early endosome membrane
CC IEA GO:0042995 cell projection
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Gene expression in normal tissue: SH3GL1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 18LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5

Gene-drug pathway distribution

undefined8Chromatin histone acetylation1Protein stability and degradation1Mitosis1p53 pathway1

Pathways in SH3GL1


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Database
Pathway ID
Pathway Des.
pid fak_pathway Signaling events mediated by focal adhesion kinase
kegg hsa04144 Endocytosis - Homo sapiens (human)
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1643685 Disease
reactome R-HSA-177929 Signaling by EGFR
reactome R-HSA-182971 EGFR downregulation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD945 ML214 3
iGMDRD451 Serdemetan 3
iGMDRD300 Tozasertib 3
iGMDRD280 CYTOCHALASIN B 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SH3GL1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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