NEDD8
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neural precursor cell expressed, developmentally down-regulated 8 | MIM:603171 | Ensembl:ENSG00000129559 | HGNC:HGNC:7732 | PA31537 | 14q12 |
GO terms in NEDD8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0031386 | protein tag |
| MF | IBA | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IBA | GO:0070628 | proteasome binding |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | TAS | GO:0006508 | proteolysis |
| BP | TAS | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:0006879 | cellular iron ion homeostasis |
| BP | IEA | GO:0008104 | protein localization |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | IBA | GO:0016567 | protein ubiquitination |
| BP | IBA | GO:0016567 | protein ubiquitination |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IBA | GO:0019941 | modification-dependent protein catabolic process |
| BP | IBA | GO:0030162 | regulation of proteolysis |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | IBA | GO:0045116 | protein neddylation |
| BP | IDA | GO:0045116 | protein neddylation |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: NEDD8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEDD8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-2173789 | TGF-beta receptor signaling activates SMADs |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689603 | UCH proteinases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8951664 | Neddylation |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-917937 | Iron uptake and transport |
| biocarta | p27pathway | regulation of p27 phosphorylation during cell cycle progression |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | erb_genomic_pathway | Validated nuclear estrogen receptor beta network |
| pid | p53regulationpathway | p53 pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD226 | ML006 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEDD8
CLASSFICATION
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